Opening Ceremony and Deichmann Lecture[Keynote Lecture]
NO.:1
ICT 2025 Award Lecture: New pollutants study in China: History, progress and challenges
NO.:2
Toxicology – the Now, the New and the Next
CEC01: Advancing Scientific Excellence and Increasing Confidence in NAMs Through Good In Vitro Method Practices (GIVIMP)[Continuing Education Courses (CEC)]
The landscape of pre-clinical testing is shifting with the introduction of novel test systems like microphysiological systems and other cell-based models, instead of relying on animal models. In response to regulatory imperatives for transitioning to these human-relevant models, scientists are turning to the development and routine use of New Approach Methodologies (NAMs). This continuing education course is designed to acquaint professionals with the principles and practices outlined in the OECD guidance document 286 – Good In Vitro Method Practices (GIVIMP). Starting with an exploration of the foundational principles shaping GIVIMP, the course emphasizes its role not only in ensuring high standards for study performance but also in influencing the design and development of NAMs. Participants will be presented with a summary of topics such as roles and responsibilities; facility design; apparatus, materials, and reagents; test systems; standard operating procedures; and the recording and reporting of results. The course illustrates the integration of GIVIMP recommendations into a variety of laboratory settings through the use of several case studies. The overarching goal is to empower scientists with the knowledge and tools essential for navigating the intricacies of in vitro methods, thereby upholding the highest standards of quality and reliability across diverse laboratory settings.
President:
NO.:1
Founding principles of GIVIMP
NO.:2
Good In Vitro method practices (GIVIMP) overview
NO.:3
Test System Strategies: Applying GIVIMP to Improve NAMs
NO.:4
Taking advantage of GIVIMP during method development
NO.:5
Applying GIVIMP in a Respiratory Laboratory
NO.:6
Application of GIVIMP principles to a laboratory in China
NO.:7
Impact of increased confidence in NAMs on acceptance in China and beyond
CEC04: Episkin Academy Training[Continuing Education Courses (CEC)]
Episkin Academy Training is a course that gives attendees a tour of reconstructed tissue models and covers the best ways to use them in applications and validated methods. Attendees will have the opportunity to realize by themselves skin and eye irritation tests with unknown products. The course is taught by highly experienced scientists from L’OREAL and includes lectures (inspired by OECD guidelines (TG431, TG439, TG492), SOPs) and hands-on exercises that provide real-world experience. It will also integrate an introduction on next-generation risk assessment process (NGRA), which is an exposure-led, hypothesis-driven risk assessment approach that integrates existing knowledge with in silico, in chemico, and in vitro approaches. Particpants will have an overview of each step of next-generation risk assessment process (NGRA) applied on cosmetics safety.
NO.:1
The integration of new methods and approaches in the safety assessment of cosmetic ingredients in Europe in the context of animal testing ban
NO.:2
Overview of Integrated Approaches to Testing and Assessment (IATA) process and its application in regulatory toxicology
NO.:3
methodology for eye hazard identification validated by OECD
NO.:4
On site operation demonstration and hands on training of SkinEthic™ RHE irritation & corrosion testing and SkinEthic™ HCE eye irritation testing
CEC02: From the Past to the Present: does Particle Toxicology Really Change?[Continuing Education Courses (CEC)]
Particle toxicology investigates the harmful effects of particles and fibres on living organisms, primarily human health. These materials originate from diverse sources, including industrial processes, pollution, construction, and natural environments. Understanding their toxicological properties is essential for risk assessment, regulatory development, and protective measures. Particles are found in air, food, water, and other matrices, leading to various exposure routes. Airborne particles, classified by size, can be coarse (2.5-10 µm), fine (<2.5 µm), or ultrafine (<0.1 µm). The latter two are particularly concerning due to their ability to penetrate deep into the respiratory system. Fibers, elongated particles, can be natural (e.g., asbestos) or synthetic (e.g., carbon nanotubes). Certain fibres are linked to severe health conditions, such as lung cancer. Particles and fibres induce toxic effects depending on their physicochemical characteristics, exposure concentration, and dose. Adverse health effects include respiratory and gastrointestinal problems, cardiovascular diseases, cancer, and neurological disorders. This course aims to provide up-to-date information on critical aspects of particle toxicology, including sample preparation, dosimetry, biodistribution, and toxicity at the port of entry and secondary organs. By understanding these aspects, we can develop effective risk management strategies and promote human health.
NO.:1
From reactionary to anticipatory toxicology, we have come a long way
NO.:2
From exposure to dose: the use of dosimetry models for In Vivo and In Vitro studies and information on biodistribution upon inhalation
NO.:3
Toxicology of ingested particles
NO.:4
Developmental Toxicity of (Nano)particles: The State of the Science
CEC05: The Emerging Psychoactive Drugs: Epidemiology, Consumption Modes, and Toxicities[Continuing Education Courses (CEC)]
The panorama of the new psychoactive drugs is enriched day by day with emerging toxicities and novel mechanisms of drug action. Some come from the diversion of drugs sold in pharmacies and others come directly from chemical synthesis carried out in clandestine laboratories. The opioid overdose epidemic alone killed 120,000 people in the United States in 2023. But other similarly dangerous substances are spreading worldwide despite surveillance and restrictive legislation. The objective of this CEC is to make an updated review of these new psychoactive substances, the involved chemistry structures and toxic consequences of their use. Scientists and clinical toxicologists need to adopt novel ways of capturing data on the epidemiology of use and potentials for toxicity related these novel substances. This session will be focused on a translational approach covering areas from mechanistic and epidemiological studies through to clinical data from poisoned patients. We will give an overview of the approaches used to investigate the patterns of toxicity of these molecules sweeping the spectrum of the novel stimulant, sedative and hallucinogenic drugs.
NO.:2
The synthetic cannabinoids
NO.:3
The NBOMe and new hallucinogenic designer drugs
NO.:4
Gamma-hydroxybutyrate and analogues
NO.:5
The fentanyloids and non-fentanyl synthetic opioids
NO.:6
Ketamine and the novel arycyclohexamines
NO.:7
Discussion
CEC03: Utilizing Computational Methods to Infer Dose-response Relationships in Chemical Risk Assessment[Continuing Education Courses (CEC)]
Computational methods are increasingly vital in modern chemical risk assessment, offering innovative approaches to infer dose-response relationships. The next-generation chemical risk assessment paradigm seeks to supplement and eventually supplant traditional animal-based toxicity testing through New Approach Methodologies (NAMs). This continuing education course session highlights recent advancements in leveraging computational tools to improve chemical safety evaluation. The first presentation introduces a mode of action (MOA)-based probabilistic dose-response modeling framework that integrates data from multiple sources to estimate reference doses (RfDs). The second presentation demonstrates the application of quantitative in vitro-in vivo extrapolation (IVIVE) to translate in vitro data into in vivo equivalent doses using the Integrated Chemical Environment (ICE) tool. The third presentation explores Bayesian benchmark dose (BMD) estimation of toxicogenomics data, providing insights into deriving genomic points of departure. The final presentation showcases mechanistic modeling of complex toxicity endpoints by organizing high-throughput screening (HTS) data into adverse outcome pathway (AOP) models. Together, these presentations illustrate how computational methods enhance chemical risk assessment by integrating diverse data streams, improving dose-response modeling, and addressing uncertainty and variability.
President:
NO.:1
An MOA-based dose-response modeling framework to integrate data from multiple sources for reference dose (RfD) estimation
NO.:2
Bayesian benchmark dose estimation of genomic data
NO.:3
Application of quantitative in vitro-in vivo extrapolation (IVIVE) to estimate reference doses from NAM Data
NO.:4
Mechanistic modeling of complex toxicity endpoints using public concentration-response metadata
CEC06: Advanced Toxicological Topics for Study Directors of Nonclinical Studies[Continuing Education Courses (CEC)]
An introductory study director course was held in China in 2019 and was developed to provide continuing education for Study Directors with up to five years of experience. Study Directors are conducting more complex studies with new modalities and with new methodologies that include gene or cell therapies, complex biological products, oligonucleotides, drug conjugates, etc. The outcome of nonclinical studies requires the Study Director to have an in-depth knowledge of the complexity of these drugs and drug products as well as the biological response to the administration of these substances. The tentative topics to be covered include nonclinical testing for biologics, gene and cell therapies, developmental and reproductive toxicology, carcinogenicity and advanced topics for study directors at all levels. Although this course is directed towards toxicologists and related professional in toxicological testing laboratories, this course would be valuable to a broad range of nonclinical, clinical, management and regulatory personnel across all industrial and governmental sectors. Regulatory and managerial personnel will gain a thorough working knowledge of preclinical development to facilitate planning, project management and development nonclinical regulatory strategies. The course will cover practical topics that apply to the interpretation, summarization and reporting of study results for any data collected and will include a separate lecture on the requirements of the Chinese FDA. If time permits, a panel discussion will be convened at the end of the session.
President:
NO.:1
Introduction to study director course
NO.:2
Complex methods and study designs for developmental and reproductive toxicology
NO.:3
Scientifically sound data interpretation and report writing for toxicology studies
NO.:4
Complex Study Director Issues and Resolution
NO.:5
The use and application of in vivo, in vitro and in silico models, artificial intelligence and ICH S1B
NO.:6
Study Director Training: Considerations from a Toxicology Study Monitor
WuXi AppTec Seminar: Changing Drug Development Landscape With New Modalities Such as Antibody Drug Conjugates (ADC)[Special Seminars]
NO.:1
Kickoff: Changing drug development landscape with new modalities such as ADC
NO.:2
Overall introduction and ADC background
NO.:3
Regulatory-compliant genetic and in vitro toxicology assessment for ADCs
NO.:4
Overcoming the challenges for detecting the antibody in ADC drugs: Using ligand binding assay and LC-MS/MS assays for different cases
NO.:5
Pathology, off-target and on-target effects
Elsevier Seminars: Symposium on Gen AI in Scientific Publishing[Special Seminars]
Generative AI (GenAI) is playing a transformative role in scientific publishing and the entire research process, reshaping knowledge discovery and innovation. As researchers increasingly adopt GenAI tools to sift through vast amounts of literature, summarize findings and analyze complex datasets, the technology enables them to enhance research efficiency, facilitate knowledge discovery and communications, and foster interdisciplinary and cross-sector collaboration, paving the way for innovative insights. It is also widely utilized in editorial workflows, such as recommending reviewers, matching suitable journals, performing technical checks, and detecting plagiarism.
However, the rapid adoption of GenAI also raises unprecedented ethical questions. It is essential to promote the responsible use of AI and raise awareness of the associated policies to ensure transparency and accountability, thereby upholding research integrity. A joint commitment from the research community and key stakeholders will be crucial in mitigating potential risks, ensuring that AI serves as a reliable technology. There is a pressing need for reliable AI-powered tools based on advanced technologies but also trustworthy content to help ensure that knowledge discovery remains rigorous and reliable. With a better understanding of the challenges, opportunities, and resources in AI adoption, we can together explore how to fully realize the benefits of this powerful technology to drive scientific progress.
President:
NO.:1
Welcome, opening, introduction
NO.:2
Knowledge discovery and scholarly publishing in the AI era: Harnessing tools and navigating responsibilities
NO.:3
Knowledge Discovery and Scholarly Publishing in the AI Era: Harnessing Tools and Navigating Responsibilities'
NO.:5
Closing
NO.:6
Post meeting communication; Demo and trail of Scopus AI, SD AI
Conference Keynote Speech[Keynote Lecture]
NO.:1
50 years of immunotoxicology: Past, present and future
NO.:2
Nanotoxicology: Expanding the cognitive boundaries of classical toxicology
NO.:3
A 40 year journey on the neurotoxicity of heavy metals: From worms to humans
NO.:4
Avoiding a reproducibility crisis in regulatory toxicology – on the fundamental role of standardisation and ring trials
Session 01: The Serious Issue of Interference in Nanotoxicology[Symposium Program （Session）]
Nanotoxicology is defined as the study of the adverse effects of nanomaterials on living organisms and the ecosystems. In vivo and in vitro test systems are implemented to characterize nanomaterial induced toxicity and elucidate mode of action involved with the aim of prevention and amelioration of such adverse effects. To this end, validated test methods that are developed for conventional chemicals are required to further be validated if they are to be used for nanomaterials. In the literature, numerous publications investigating the toxicity of nanomaterials have implemented these test systems without giving due consideration to the possibility of nanomaterials interfering with these test systems. There are different ways that nanomaterials interfere with these assay systems which include absorption, adsorption, or by interacting with the substrate and/or product. They may also enhance or quench the intensity of fluorophores or have catalytic activity. Ignoring this aspect in nanotoxicology may lead to the production of erroneous results and in turn hinder the elucidating mechanisms of toxicity to help in the prevention and amelioration of the observed adverse effects.
For these reasons, time has come for scientific journals to reject work that still use assay systems that are known to produce interference by nanomaterials.
NO.:1
In vitro toxicity assays: Potential assay interferences by nanomaterials
NO.:2
In vitro toxicity assays: Potential assay interferences by carbon-based nanomaterials
NO.:3
Necessity of accurate assessment of the rate limiting step in initiation of inflammation
NO.:4
Serious concern with big data: Criteria for journals to accept publications using assay systems with interference
Session 07: Organoids and Organ-on-a-chip in Toxicology[Symposium Program （Session）]
This session is dedicated to presenting reports on the technological advancements and applications of cutting-edge analytical platforms in the field of toxicology, with a particular emphasis on organoid and microphysiological system (MPS) platforms, as well as integrations with AI technology. Microphysiological systems, recognized as one of the World's Top 10 Emerging Technologies at the Davos Forum in 2016 and endorsed by the FDA 2.0 and FDA 3.0 frameworks, represent the forefront of in vitro toxicological research systems. This forum aims to assemble a distinguished panel of experts in MPS research, comprising Prof. Dan Tagle, the director of the US MPS Consortium, Prof. Uwe Marx, the chief scientist at TissUse, a pioneering German organ-on-a-chip enterprise, Prof. Thomas Hartung from Johns Hopkins University, Professor Jay Hickman affiliated with both Cornell University and Hesperos Inc., Prof. Seiichi Ishida from NIEH in Japan, and Dean and Prof. Gu Zhongze from Southeast University in China. These esteemed scholars will introduce novel technological paradigms for toxicological research and application, encompassing various microphysiological systems that mimic different human organs and spanning multiple model frameworks.
NO.:1
The innovation of organ-on-a-chip in toxicology research
NO.:2
Introduction of the development of MPS in Japan and their way to the regulatory acceptance
NO.:3
Human multi-organ-chips advancing from toxicology testing toward preclinical “safficacy” evaluation in vitro
NO.:4
Qualifying the soluble and mechanical environments of microphysiological systems for enhanced regulatory utility
Session 02: Toxicity of Opioids: New Insights to Understand and Face the Progressing Threat[Symposium Program （Session）]
Opioid abuse and misuse are serious problems in developing countries. The increasing availability of analgesic opioids, recreational opioid-like drugs, and maintenance treatments for heroin addiction represents sources of abuse. Postmortem clinical findings and toxicological analysis in opioid-attributed deaths are very helpful to inform about the exact mechanisms of death, including the roles of tolerance, abstinence, drug abuse and drug–drug interactions. Experimental studies and clinical observations in human poisonings are able to identify possible mechanisms of toxicity, some of them being common to the different opioids, while others are specific to each marketed opioid molecule like codeine, methadone, buprenorphine and tramadol. Opioid-induced glial activation opposes opioid analgesia and enhances opioid tolerance, dependence, reward and respiratory depression. Such effects can occur, not via classical opioid receptors, but rather via non-stereoselective activation of toll-like receptor 4 (TLR4), a recently recognized key glial receptor participating in neuropathic pain as well. One recent strategy to increase opioid-related antinociceptive properties and overcome major side-effects involves the creation of multifunctional compounds which contain hybridized structures, including the combination of opioids with other bioactive neurotransmitters and peptide hormones involved in pain perception.
NO.:1
Toxicological and pathological findings in opioid-related deaths
NO.:2
Opioid-related mechanisms of neuro-respiratory toxicity: Interindividual variability and drug-drug interactions
NO.:3
Engineering hybrid peptidomimetics for improved pain treatments
Session 08: Pesticide and Herbicide Exposure: From Risk Assessment to Morbi-mortality Reduction[Symposium Program （Session）]
The use of pesticides/herbicides still seems necessary to feed humanity, especially in overcrowded or developing countries. In the developing countries, pesticide-free agriculture has also failed to prevail. The use of these chemicals is associated with vital risks in acute exposure and a health hazard in chronic exposure, particularly in exposed workers. The whole toxicological scientific community tries by multiple approaches to understand the mechanisms of toxicity involved and to limit their scope by regulatory measures, risk assessment and monitoring, and measures to improve intoxicated patient management. The objective of this symposium is to make an updated inventory of the scientific progress in each of these areas and to verify its effectiveness on morbidity and mortality possibly induced by pesticide/herbicide exposure.
President:
NO.:1
Mixed organophosphate poisoning: An emerging toxicological crisis in LMICs
NO.:2
Acute pesticide exposure & antidote therapy
NO.:3
Glyphosate: Toxicity, cancer risk and the role of the formulation
NO.:4
Pesticide regulations & impact on mortality by suicide
Session 03: Systemic and Next Generation Toxic Effects of Inhaled Carbonaceous Ultrafine Particles[Symposium Program （Session）]
NO.:1
Investigation of the priming effect of inhaled carbon nanoparticles on the lung
NO.:2
Small particles, big impact: Neurotoxic effects of early-life exposure to ultrafine carbonaceous particles
NO.:3
Early-life exposure to ultrafine particles from air pollution affects proximal tubular epithelial cells development and resilience
NO.:4
Aircraft Cabin air quality assessment of pulmonary and neurological effects of contaminants including ultrafine particles
Session 09: Interdepartmental Alternatives, Reductions, and Optimizations of Acute Toxicity Tests[Symposium Program （Session）]
President:
NO.:1
Refining and removing global requirements for mammalian acute toxicity testing across sectors
NO.:2
Applying the 3Rs in fish acute toxicity tests for chemicals safety assessments
NO.:3
Case studies for assessing acute oral toxicity without animal testing for cosmetic ingredients
NO.:4
Progress with assuring consumer safety of cosmetics without animal testing
Session 04: Modernising Approaches to Safety Assessment through Use of In Silico Approaches in Decision-making[Symposium Program （Session）]
In silico/computational approaches can provide useful information to inform chemical safety assessment. These methods are being increasingly used across all sectors for internal decision-making and there are moves towards application within a regulatory context. These approaches have the potential to decrease the current reliance on traditional toxicity testing in animals (e.g. through use for screening and/or prioritization) but can also be used to inform and/or improve studies that may still need to be conducted in animals (e.g. to inform dose or species selection). In silico approaches are higher-throughput and less resource-intensive and therefore are associated with reduced animal use. They can also increase testing and predictive capacity to improve safety assessments. This session will showcase collaborative examples of how developers and industry-users have worked together to increase confidence in, and acceptance of, in silico-based approaches for safety assessment.
President:
NO.:1
Opportunities for the use if in silico NAMS within next generation risk assessment of cosmetic ingredients
NO.:2
Development of in silico tools based on curated toxicological databases
NO.:3
An end-user perspective on supporting the development of a QSAR model to predicts human respiratory irritancy of single compounds and mixtures
NO.:4
Drug safety and efficacy evaluation using AI-informed modelling & simulation
Session 10: PARC – New Approaches to Model Kinetic Properties[Symposium Program （Session）]
The PARC project (Partnership for the Assessment of Risks from Chemicals) aims to close data and knowledge gaps for priority compounds by developing NAM based assessments. The understanding of the absorption, distribution, metabolism and excretion of xenobiotic compounds a central assessment element in vitro to in vivo extrapolation and therefore of high importance for next generation risk assessment. Organised in four presentations, the symposium will provide insights into physiological based kinetic modelling approaches, which will evaluate the kinetic properties of Alternaria toxins and enniatins. To date, there are no PBK models for these emerging mycotoxins in any species. The talk will present a first modelling attempt using in vitro and in silico data (NAMS). It will discuss how bottom-up PBK modelling, as presented here, will facilitate the scientific community to adopt alternative ways to improve the assessment of ADME, whether common or specific to each of these toxins.
- develop a tiered testing strategy for volatile compounds. Different in vitro barrier models will be compared to model their absorption within the different regions of the respiratory tract.
- assess the impact of the human microbiome on the biotransformation of chemicals and their uptake into the systemic circulation.
President:
NO.:1
A tiered testing strategy to assess absorption of volatile compounds
NO.:2
First physiologically based modeling of Alternaria toxins
NO.:3
Quantifying the gut microbiome’s impact on toxicokinetics by physiologically based kinetic (PBK) modeling
NO.:4
PBK model-based QIVIVE for a NAMs based assessment of emerging mycotoxins
Session 05: Unlocking the Future of Safety: New Approach Methodologies (NAMs) and Microphysiological Systems (MPS)[Symposium Program （Session）]
New approach methodologies (NAMs) can provide the necessary information for chemical risk assessment without using animal tests. Significant advancements have been made in developing tools like computational models, microphysiological systems, and ‘omics’ technologies. However, there is often a lack of confidence in applying these methods within a regulatory setting. This symposium aims to raise awareness of NAMs and explore how their regulatory application can be accelerated by overcoming significant barriers. Key objectives include showcasing current uses of NAMs, identifying barriers and scientific gaps, and exploring ways to speed up validation and qualification. Many guidelines exist for developing and adopting new in vitro toxicological test methods, which are now routinely used to evaluate drug and chemical safety. Microphysiological systems (MPS) or tissue chips may address shortcomings in drug development by improving clinical efficacy and eliminating the need for animal-to-human extrapolation. Despite their promise, the complexity and cost of these models’ present adoption challenges. This symposium will bring together experts to discuss building confidence in using microphysiological systems as decision-informing tools in regulatory science.
NO.:1
Fit for purpose evaluation of a NAM-based systemic toxicity toolbox
NO.:2
The significance of mechanistic evidence in NGRA: is key characteristics-structuralized NAMs a reasonable approach?
NO.:3
A pharma perspective on the use and utility of MPS for drug safety assessment
NO.:4
Perspective on qualification of the microphysiological systems for regulatory use
Session 11: The Westward Movement of Botanicals[Symposium Program （Session）]
Humans have been looking after their health for thousands of years. From ensuring the balance of ‘humors’ to cold-water therapy, our understanding of health continues to evolve. While health and ill health were initially “dictated by the Gods”, the ancient Greeks were the first to look at human biology. Eastern medicine refers to various organically integrated practices encompassing spiritual, social, and temporal health determinants and underscores illness prevention. Standardized formulations of botanical mixtures and herbal extracts, informed by centuries of use, are adjusted to novel indications and to respond to specific patient characteristics and lifestyles. Here, the future may lie in the improved recapitulation of ancient Eastern approaches married to modern Western technology informed by ancient experience. This session aims to provide an overview of the westward movement and the scope of key botanicals being promoted for improved health. In addition, safety considerations and regulatory pathways that allow for premarket approval in the European Union and North America, including US FDA GRAS (generally recognized as safe) and NDI (new dietary ingredient) paradigms, will be discussed.
President:
NO.:1
The western movement
NO.:2
Generally recognized as safe/new dietary ingredients
NO.:3
Botanicals and herbal medicines
Session 06: Safety Assessments for Dietary Supplements and Herbal Products[Symposium Program （Session）]
According to the WHO report, Traditional and Complementary Medicine (T&CM) is an important health resource in many countries, especially in Asian countries. T&CM products include herbs, herbal preparations, and herbal products. There is an increasing global interest in the use of botanicals or derivative products because people believe that such products as “natural” may be beneficial to health. However, the complex chemical nature of herbal dietary supplements makes it difficult to evaluate their efficacy and safety. The reported adverse effects have raised concerns of public health risks regarding the concentration, composition, and individual contaminants of herbal supplements. The WHO Traditional Medicine Strategy has announced to strengthen quality assurance, safety, proper use, and effectiveness of T&CM; and the International Agency for Research on Cancer (IARC) has assessed the carcinogenicity of some herbal products, and part of them are classified as Group 2B (possibly carcinogenic to humans). Since little has been done to determine the potential risks associated with prolonged or high-dose use of herbal products, toxicological profiles of many herbal products that are currently on the market need to be scientifically evaluated. In this proposed symposium, safety issues about the herbal products will be discussed by scientists from different countries.
President:
NO.:1
The serious adverse reactions due to the adulteration of herbal products with chemicals and synthetic drugs
NO.:2
ecNGS reveals increased hepatocarcinogenic risk of aristolochic acid under steatohepatitis inflammation
NO.:3
The balance between safety and efficacy for the approvement of dietary supplements in Korea
NO.:4
Malaysia’s safety framework for herbal and dietary products
Session 12: The Science, Application and Management in Risk Assessment[Symposium Program （Session）]
In the past several years, many new regulations and standards have been issued for the safety/risk assessment of chemicals and consumer goods in China, such as multiple guidelines for cosmetic safety assessment issued by the National Medical Products Administration (NMPA), the technical guidelines for environmental and health hazard assessment of chemical substances (trial) issued by the Ministry of Environmental Protection, etc. Meanwhile, new approaches like NAMs, NGRA and IATA have been developed and gradually transformed for safety assessment. From regulatory agencies, higher attention has been paid to the safety of chemicals and products, and higher requirements have been put forward for safety assessors. Therefore, to advance science and better enable the practice of risk assessment in China, we will conduct a symposium plus roundtable discussion afterwards for theme of “the science, application and management in risk assessment”, which will invite both international and domestic speakers to share and exchange the challenge and opportunity together. Hopefully this will strengthen the confidence of risk assessment practice in China.
NO.:1
The future is now: Implementing animal-free safety assessment for cosmetics
NO.:2
The development, challenge and opportunity of risk assessment in China
NO.:3
Use of NAMs to refine and strengthen SAR read-across
NO.:4
Discussion on the practice of safety assessment for cosmetics under regulatory framework in China
Young Scientist Lecture 01：Advances in Feed Safety and Toxicology: From Detection and Toxicological Evaluation to Risk Management and Control[Symposium Program （Session）]
NO.:1
Potential Toxicity and Mechanisms of AFB1 and DON Individual Exposure or Co-Contamination on the Damage of HepG2 Cells
NO.:2
Novel Technologies for Detection of Small-Molecule Pollutants in Feedstuffs
NO.:3
Artificial Intelligence Accelerates the Transformation of Nanotoxicity Data into Critical Information
NO.:4
From Detection to Toxicity: Unraveling Metabolic Processes and Toxicological Mechanisms of Zearalenone and Deoxynivalenol
NO.:5
Multi-Omics Revealed the Biomarkers and Potential Response Mechanism of Taihe Black-Bone Chickens to Salmonella Pullorum Invasion
NO.:6
Active Detoxification of Nanoplastics-Induced Hepatic Ferroptosis with Nano-Selenium
NO.:7
Defatted Rice Bran Attenuates Inflammation Index and Modulates Gut Microbiota–SCFAs Axis in Colitis-Associated Colorectal Cancer
NO.:8
Effects of phthalate exposure on the male reproductive system and antagonism of lycopene
Young Scientist Lecture 02：AI-empowered Computational Toxicology[Symposium Program （Session）]
NO.:1
AI for Toxicology - An Case Study on Deep Learning-enabled Morphometric Analysis (DLMA) for High Throughput Toxicity Screening
NO.:2
Integrating PBTK Modeling-Based Reverse Dosimetry and In Vitro-In Silico Bioassays to Derive a Health-Based Guidance Value for 9,10-Anthraquinone: A NAMs Perspective
NO.:3
Deep Learning-based 3D Vascular Morphologic Phenomics empowered the Discovery of Vascular-disruptors
NO.:4
Using Environmental Mixture Exposure Triggered Biological Knowledge-Driven Machine Learning to Predict Reproductive Health Outcomes
NO.:5
From Specific Targets to Global Prediction: A Multi-Model Approach for Assessing PFAS Liver Toxicity
NO.:6
Toward Smart and Sustainable Screening of Endocrine-Disrupting Chemicals: A Knowledge-Coupled, AI-Powered Framework
NO.:7
Machine Learning Models for Screening Hazardous Chemicals and the Applicability Domain Characterization Methodology
NO.:8
Integrative Systematic Evidence Mapping and In Silico Molecular Docking for Prioritizing Plastic Additives Leaching from Polymers
Young Scientist Lecture 03：Artificial Intelligence Toxicology and New Technologies and Methods[Symposium Program （Session）]
President:
NO.:1
Multi-organs-on-a-chip platform development and application in toxicology research
NO.:2
Advancing Toxicology through AI Integration with C.elegans
NO.:3
Developmental neurotoxicity assessment of consumer product chemicals using machine learning and C. elegans models
NO.:4
A Safety-by-Design Framework for De Novo Anti-Aging Peptides with AI Toxicity Screening in C. elegans
NO.:5
Evidence-Based Practice: Clinical Diagnosis and Treatment of Acute Diquat Poisoning
NO.:6
Safe and Efficient Precision Delivery System Based on Guanidinyl Macromolecules
NO.:7
Engineer advanced Microphysiological Systems for Drug Toxicology
NO.:8
Nanoengineered Red Blood Cells and Stem Cell Derivatives for Targeted Therapy
NO.:9
Constructing a Model for Evaluating Pulmonary Toxicity of Environmental Pollutants Using Gene Editing Technology
NO.:10
Computational Biology and AI-Empowered Research on Radiation Injury
NO.:11
The repair effects and mechanisms of Gut microbiota-derived bile acids on radiation-induced intestinal injury
NO.:12
Regeneration of Intestinal Stem Cells after Radiation Injury - Main Hypotheses and Progress
NO.:13
Mechanism of NRP1-MAMs in Regulating Mitochondrial Metabolic Reprogramming and Radioresistance in Non-Small Cell Lung Cancer
NO.:14
Heatwave and lung inflammatory injury: repair disorder mechanism of club stem cells
Young Scientist Lecture 04：Environmental Toxicology and Molecular Toxicology[Symposium Program （Session）]
President:
NO.:1
F-53B Induces Renal Fibrosis through the Crosstalk Between TGF-β1/Smad3 and NOTCH Signaling Pathways
NO.:2
Metal ion exchange regulates cell contraction and matrix remodeling in renal fibrosis via RAP2-ANKRD1 axis
NO.:3
Phytohemagglutinin-induced NF-κB/MAPK activation broadly upregulates immune checkpoint expression in human lymphocytes
NO.:4
Hemolysis Defines the Etiology of Pyrrolizidine Alkaloid-Induced Hepatic Sinusoidal Obstruction Syndrome
NO.:5
Mechanisms of Manganese-Induced Neurotoxicity and Potential Intervention Strategies: An Epigenetic Perspective
NO.:6
Methionine intervention in cognitive impairment caused by low-levels of lead, mercury and cadmium mixture exposure
NO.:7
Elemental Exposure and Attention Deficit Hyperactivity Disorder Risk in Youths Aged 6-16 Years: Associations and Potential Mediation by Oxylipins
NO.:8
Arsenic trioxide suppressing H3K9me3-HMOX1 triggers ferroptosis and induces cardiotoxicity
NO.:9
Potential Lead (Pb) Exposure in School: Kids Health Concern
NO.:10
Effects of chemical speciation on chronic thyroid toxicity of representative perfluoroalkyl acids
NO.:11
The Toxic Effects of Microplastics on Ovarian Function and Potential Therapeutic Approaches
NO.:12
ALKBH5- regulated MICU1 methylation participates in precise mitochondrial degradation induced by cobalt nanoparticles
NO.:13
Cross-species molecular docking approaches to predict the susceptibility of plastic additives in endangered species
NO.:14
Assessing the impact of plastic pollution from land to ocean on shorebirds
Session 13: Mapping Human Immune Development and New Approach Methodologies to Test Its Vulnerability to Toxicants[Symposium Program （Session）]
Interest in developmental immunotoxicity (DIT) has grown due to the rise in immune-mediated developmental disorders in children linked to environmental exposures. The developing immune system is particularly sensitive to chemical and environmental stressors during critical prenatal and postnatal periods, leading to long-term dysfunction. Understanding age-related vulnerability to immunotoxicants is crucial. Recent advances have filled critical knowledge gaps about the developing immune system. Efforts to map human immune development using high-dimensional cytometry, single-cell RNA sequencing, antigen-receptor sequencing, and spatial transcriptomics have provided valuable insights. Immune mapping from infancy to early adulthood has enhanced our understanding of how aging influences immune responses and disease susceptibility. Such human immune cell atlas is also vital for investigating DIT risk. Traditionally, DIT risk assessments relied on animal models, with limited endpoints and developmental windows, and limitations in scalability, high-throughput, and human translatability. Developing predictive NAMs is essential to better understand DIT and for evaluating more chemicals across a broader range of biological effects in a shorter timeframe with fewer resources. This session will convene immunologists and toxicologists to discuss the latest advances in human immune mapping, challenges in developing precise, predictive, and translatable NAMs for DIT, and explore examples with high potential for regulatory screening.
President:
NO.:1
Developmental immunotoxicity testing: Challenging the status quo
NO.:2
An immune map of human body across ages and sexes based on single-cell deconvolution
NO.:3
Microfluidic models of human bone marrow and lymph node for immunotoxicity studies
NO.:4
Human umbilical cord blood derived CD34+ hematopoietic stem cells as an in vitro model for investigating developmental immunotoxicity
Session 19: Assessing the Exposure and Toxicity of Emerging Toxicants in Humans[Symposium Program （Session）]
Emerging toxicants encompass chemical substances recently identified as potentially harmful to human health or the environment yet not extensively studied or regulated. These substances include microplastics, nanomaterials, per- and poly-fluoroalkyl substances (PFAS), pharmaceutical drugs, pesticides, personal care products, and other compounds. Monitoring and researching these substances are crucial to better understand their effects and develop appropriate regulations to protect public health and the environment. This symposium aims to underscore the critical importance of assessing exposure and health effects of emerging toxicants in human populations. As our environment evolves, new substances emerge, posing challenges to toxicological evaluation. This symposium will convene leading experts to delve into innovative methodologies and state-of-the-art research focusing on human population exposure assessment and associated health effects of emerging toxicants. Topics will encompass advancements in biomonitoring techniques, identification of novel toxicants, exploring toxicant exposure levels in different populations, and assessing the impact of toxicants on human health through population-based studies or human subjects’ research. By fostering collaboration and knowledge exchange, this symposium seeks to deepen our understanding of emerging toxicants' impacts on human health and inform strategies for mitigating associated risks.
NO.:1
Old and new insights in the respiratory toxicity of carbon-based nanomaterials
NO.:2
Children's third-hand smoke exposure assessment
NO.:3
Rethinking health in the face of modern environmental risks: The role of exposomics
NO.:4
Leveraging pulmonary nanotoxicological discoveries for the design of inhalable nanotherapeutics
NO.:5
Toxicity of electronic cigarette aerosols
Workshop 01: Drug Toxicology and Drug Safety Evaluation[Workshop]
This seminar focuses on the specialized topics of Drug toxicology and drug safety evaluation, featuring senior pharmacotoxicology experts from China and the United States, as well as professors with extensive research experience in multinational pharmaceutical companies. The event aims to analyze and discuss current hotspots and challenges in pharmacotoxicology research. Through presentations by leading experts from both China and the U.S., attendees engaged in pharmacotoxicology and non-clinical evaluation studies will gain substantial insights and inspiration to advance their work.
NO.:1
Developing Non-Clinical Safety Assessment Strategy for New Drug Development
NO.:2
Special considerations in conducting an enhanced pre- and postnatal development (ePPND) study in cynomolgus monkeys of biotherapeutics
NO.:3
Key considerations and case studies in non-clinical research of cell therapy products for solid tumors
NO.:4
Nonclinical safety strategies for cancer immunotherapies
NO.:5
Workshop 02: Application of Synchrotron Radiation Techniques in Toxicology[Workshop]
Synchrotron radiation (SR) combines high brightness, a broad energy spectrum, and tunable wavelengths, positioning it as a powerful and indispensable tool in scientific research. In the field of toxicology, SR techniques have been increasingly employed to investigate the behavior and effects of various toxic substances at the molecular and cellular levels. This workshop is designed to introduce the diverse characteristics and advantages of SR techniques and their growing applications in toxicology. By bringing together beamline experts and toxicologists, we aim to demonstrate how SR techniques can deepen our understanding of the mechanisms and effects of toxicants, particularly emerging pollutants, which present novel challenges to environmental and public health. The workshop will also introduce cutting-edge SR techniques and examine their potential applications in toxicology. Moreover, we will discuss the integration of SR data with other analytical methodologies to create a more comprehensive framework for understanding toxicological phenomena. Ultimately, this workshop seeks to stimulate interdisciplinary collaborations, inspire innovative approaches, and contribute to advancing the science of toxicology. By leveraging SR techniques, we aim to enhance our ability to assess and mitigate the risks posed by toxic substances, ultimately benefiting public health and environmental safety.
President:
NO.:1
Nanoscopic X-ray analytical techniques with synchrotron radiation to assess toxicity mechanisms of metals and nanomaterials in ecosystems
NO.:2
Synchrotron radiation-based characterization of nanomaterial biotransformation: Environmental degradation and in vivo metabolism
NO.:3
Applications of synchrotron-based scanning transmission X-ray microscopy in toxicology
NO.:4
Synchrotron-based X-ray microscopy for cell imaging
NO.:5
X-ray investigation for aqueous – biomembrane interfaces at the beamline P08 of PETRA III
NO.:6
Synchrotron radiation- and MS-based analysis of nano-bio interface: Composition, structure, and effects
Session 14: New Horizons in Environmental Toxicology[Symposium Program （Session）]
In response to the escalating release of diverse chemicals and materials into our environment, there's an urgent need for comprehensive assessments of their environmental and health risks. Join us for a dynamic exploration of "New Horizons in Environmental Toxicology," where we will delve into the latest advancements, challenges, and innovations shaping the field. This symposium will bring together leading experts and researchers to discuss emerging trends, novel methodologies, and cutting-edge findings in environmental toxicology. From understanding the impact of emerging contaminants to exploring innovative approaches for risk assessment and mitigation, attendees will gain valuable insights into the complex interactions between pollutants and ecosystems. This symposium offers a unique opportunity to engage with the forefront of environmental toxicology and contribute to the pursuit of a safer, healthier planet.
President:
NO.:1
Structural differences in oxygenated PAH developmental toxicity
NO.:2
Safe-by-design metal-phenolic network nanocomposites for environmental remediation
NO.:3
Synthesis and characterization of novel antibacterial and antifungal silver-chitosan nanocomposites: a mechanistic study
NO.:4
Chronic exposure to titanium dioxide induces commensal -to - pathogen transition in Escherichia coli
NO.:5
Protein corona and its toxicology implications
Session 20: Advancements in Reproductive Toxicology[Symposium Program （Session）]
Reproductive toxicology faces growing challenges due to emerging contaminants, necessitating advanced technologies to uncover mechanisms and improve risk assessment. While existing studies offer insights, they often fall short in addressing the complexity of reproductive health. Recent advancements in genome editing, organ-on-a-chip systems, iPSCs, and artificial intelligence enable more comprehensive approaches, facilitating targeted screening, mechanistic insights, adaptive study design, multi-omics integration, and translational research. Emerging areas like synthetic biology and microbiome-host interactions also hold promise for further exploration. The future of reproductive toxicology is poised for significant progress, driven by technological innovation and evolving research paradigms. This symposium will unite experts from toxicology, genomics, exposome research, and cell biology to discuss the latest opportunities, advances, and challenges in the field. Through interdisciplinary collaboration, we aim to deepen understanding of reproductive health risks and pave the way for impactful solutions.
NO.:1
Advancements in reproductive toxicology
NO.:2
Impact of a real-life mixture of PFAS on placental health
NO.:3
Developmental toxicology in a dish – when stem cell biology meets environmental health sciences
NO.:4
Constitutive androstane receptor regulates germ cell homeostasis, sperm quality, and male fertility via akt-foxo1 pathway
NO.:5
Research on reproductive and developmental toxicity based on the integration of exposome and metabolome analyses
NO.:6
Arsenic and the Developmental Clock: Disrupted Neurotransmission from Womb to Lifespan
Workshop 03: Heavy Metal Toxicity and Human Health-1[Workshop]
Heavy metals, including Arsenic (As), Cobalt (Co), and Lead (Pb), among others, pose substantial health risks through various exposure routes. These elements, prevalent in the environment, can accumulate in human bodies, leading to acute and chronic toxic effects.
The workshop will gather a diverse group of participants, including leading researchers, students and postdoctoral fellows to discuss the mechanisms of heavy metal-induced oxidative stress, gene expression alterations, and their broader implications on human health. The topics will also encompass the forefront of research and practical approaches towards mitigating heavy metal exposure. By fostering dialogue among experts from diverse backgrounds, the workshop seeks to enhance understanding of heavy metal toxicity's complexities and drive forward innovations in public health interventions. The goal is to equip participants with the latest knowledge and tools necessary for addressing this pressing environmental and health challenge, ultimately contributing to safer, healthier communities worldwide.
President:
NO.:1
Exposure to heavy metals and cancer
NO.:2
Crosstalk between NRF1 and NRF2 in osteoclastogenesis and osteoporosis induced by prolonged cadmium exposure
NO.:3
Investigating the Role of Histone Acetyltransferase MYST-Mediated NLRP3 Inflammasome Activation in Microglia during Lead-Induced Neurotoxicity
NO.:4
Environmental metal exposure and craniosynostosis risk
NO.:5
The role of transcription factor Nrf2 in arsenic-induced malignant transformation and its underling mechanism
NO.:6
Prenatal cadmium exposure drives Rapsn m6A modification to enhance multigenerational susceptibility of male infertility
Workshop 04: Heavy Metal Toxicity and Human Health-2[Workshop]
Heavy metals, including Arsenic (As), Cobalt (Co), and Lead (Pb), among others, pose substantial health risks through various exposure routes. These elements, prevalent in the environment, can accumulate in human bodies, leading to acute and chronic toxic effects. The workshop will gather a diverse group of participants, including leading researchers, students and postdoctoral fellows to discuss the mechanisms of heavy metal-induced oxidative stress, gene expression alterations, and their broader implications on human health. The topics will also encompass the forefront of research and practical approaches towards mitigating heavy metal exposure. By fostering dialogue among experts from diverse backgrounds, the workshop seeks to enhance understanding of heavy metal toxicity's complexities and drive forward innovations in public health interventions. The goal is to equip participants with the latest knowledge and tools necessary for addressing this pressing environmental and health challenge, ultimately contributing to safer, healthier communities worldwide.
President:
NO.:1
Risk-Based evaluation of heavy metals and disinfection byproducts in groundwater
NO.:2
Effects of metal exposome in pregnant women during pregnancy and neurodevelopmental impairment in offspring
NO.:3
Hexavalent chromium inhibits myogenic differentiation and muscle regeneration
NO.:4
Epigenetic mechanisms of metal exposure in colorectal cancer
NO.:5
Cadmium exposure promotes the progress of chronic kidney disease through Hippo pathway
NO.:6
Dissection and mechanism study of environmental Pb on cognition and mood dysfunctions
NO.:7
ER sensor protein PERK-coupled autophagy protects the cells from arsenite-induced apoptosis
Session 15: Airborne Micro- and Nanoplastics: Comprehensive Overview of Exposure, Toxicity and Risk Mitigation Strategies[Symposium Program （Session）]
Airborne nano- and microplastic particles (MNP) pose a significant environmental and public health concern due to their widespread presence and potential toxicological impacts. This session aims to advance our understanding of potential risks from airborne MNP by integrating exposure assessment, hazard identification, and risk management across the plastic life cycle. We will explore the sources and pathways of MNP, focusing on their release mechanisms and interactions with biogeochemical cycles. Advanced methodologies for detecting and quantifying MNP in the air will be discussed, emphasizing novel sampling techniques and analytical methods for assessing human exposure. To elucidate potential health effects of MNP, results of studies using new approach methodologies (NAMs) in lung cell lines and human tissue models will be shared and compared to results of recent inhalation studies in rats, covering clinical chemistry, broncho-alveolar lavage, histopathology, organ burden examinations, and transcriptomics of lung and liver tissues. The session will conclude with strategies for mitigating the risks associated with airborne MNP, exploring innovative technologies aimed at reducing MNP entry into the environment and minimizing human exposure, such as advanced air filtration systems and personal protective equipment.
President:
NO.:1
Green process value chain approach to prevent micro/nano plastics (MNP) from entering the environment
NO.:2
Advancements in aerosol measurement and aerosol filtration: A path towards a clean and sustainable environment
NO.:3
Inflammation-related key events stimulated by micro- and nanoplastics
NO.:4
Toxicological effects of inhaled micro- and nanoplastic particles: A study of polystyrene and polyamide in rats
Session 21: Safety of Recycled Plastic for Food Packaging[Symposium Program （Session）]
Plastic packaging, rPET, is the material that causes the serious pollution. It was not permitted to be used as food packaging in Thailand for long time. Recently, private and public organizations have collaborated to preserve our environment, by considering to reduce the garbage from plastic food packaging which continue increasing. One way of reducing it, the used plastic packaging can be brought back to be processed, in order to reduce the amount of new plastic, particularly rPET, used food packaging, the law of TFDA must be allowed. However, the Thai FDA in collaboration with private sectors, food and drink industries, and the academic institutions, such as Mahidol University, formed a research group to study the possibility and feasibility to allow rPET to be used. The process was done to ament the notification of Food law, but we need the result from research team including the following processes:
· The result of study on the reuse, and method of used rPET food packaging
· The study of the safety assessment process of the recycling industries, the rPET safety assessment method to test the migration by both the laboratory result and mathematical model
· The final result was compiled and submit to the sub-committee on food packaging of Thai FDA to draft the notification of food packaging to include the recycled plastic to be allowed to use
Finally, now we have the new notification on plastic to be used as food packaging. The symposium will describe some detail of the regulation items in the notification and the standards for safety. Furthermore, the process of safety assessment including the result of laboratory analyses and the mathematical model of the possible migration of chemical into food to make sure that it is safe for human consumption.
NO.:1
Regulation of Thai FDA for recycled PET plastic
NO.:2
Safety assessment process of food contact material produced from rPET
NO.:3
Surrogate migration testing using a mathematical model for safety assessment of recycled PET
NO.:4
Thailand Risk Assessment Center as the safety assessment organization of recycled plastic for food packaging
Workshop 05: Understanding and Mitigating Occupational Heavy Metal Exposure: A Comprehensive Approach[Workshop]
This workshop aims to address the critical aspects of heavy metal exposure in occupational settings and its far-reaching health and ecological impacts. Bringing together experts in toxicology, public health, environmental health, and policy, this workshop will present a multi-disciplinary overview of exposure pathways, health risks, and bioaccumulation of heavy metals such as lead, mercury, arsenic, and cadmium. Sessions will cover advanced detection and monitoring techniques for occupational exposure, emphasizing cutting-edge innovations for accurate and timely assessments. The workshop will also highlight global policy frameworks and regulatory standards governing heavy metal use, disposal, and exposure limits. Real-world case studies will offer practical insights into mitigating risks and enhancing compliance. Attendees will gain a deeper understanding of the interplay between heavy metal contamination, human health, and ecological sustainability, while also discussing sustainable interventions and regulatory challenges to foster safer industrial practices and public health protection. This workshop is geared towards researchers, practitioners, and policymakers committed to advancing occupational and environmental safety.
President:
NO.:1
Advancements in heavy metal detection and monitoring techniques: Innovations, applications, and challenges
NO.:2
The study on the repair effect and mechanism of small EVs derived from nasal mucosal mesenchymal stem cells in the treatment of manganese poisoning
NO.:3
Ecological and Human Health Impacts of Heavy Metal Contamination: Challenges and Mitigation Strategies
NO.:4
Immune regulation patterns in response to environmental pollutant chromate exposure-induced genetic damage: A cross-sectional study applying machine learning methods
NO.:5
Introduction to occupational heavy metal exposure: Pathways, risks, and bioaccumulation
NO.:6
Hexavalent chromium inhalation exposure induces metabolic reprogramming underlying lung injury and partial endogenous repair
Workshop 06: High-throughput Technology and Health Effects of Heavy Meatal[Workshop]
With the rapid advancement of technology, particularly the widespread use of high-throughput technologies in medical research, it is now possible to simultaneously detect a wide array of genes, proteins, metabolites, and other biological molecules. This has provided powerful tools for biomarker screening, early monitoring, diagnosis, and the study of mechanism for metal toxicity, including investigations into the underlying health effects and prevention strategies. Compared to traditional experimental methods, high-throughput technologies offer unique advantages, particularly in detecting metal toxicity and facilitating biological monitoring. However, challenges remain in terms of testing standards, cost, validation, and the translation of these technologies into clinical practice. In light of these issues, this workshop, organized with input from esteemed professionals in academia and specialized institutions, aims to highlight current achievements and future directions in understanding the health effects of heavy metals. The session will foster constructive dialogue and interaction, driving the field toward meaningful advancements.
The health impacts of heavy metals and industrial elements remain a critical global challenge. Heavy metals such as lead, mercury, cadmium, and arsenic pose severe risks to human health, including neurotoxicity, carcinogenicity, and endocrine disruption. These metals are encountered through sources like old paint, water pipes, cigarette smoke, contaminated soil, and industrial waste, with vulnerable populations, particularly children, facing the greatest risks. Mining and industrial activities exacerbate environmental contamination, leading to significant health and ecological impacts. Understanding the mechanisms of exposure and developing strategies to mitigate these risks are essential to safeguarding public health and ecosystems.
In parallel, the study of essential and non-essential elements, such as sulfur, selenium, and tellurium —raise concerns due to environmental pollution and health risks from their extraction and manufacturing. These metals are crucial for sustainable technologies, but managing the health risks related to their use is essential. To address these challenges, cutting-edge high-throughput technologies are being harnessed to screen the effects on biological systems, identify affected genes and pathways, and develop early warning systems for environmental contamination. These technologies enable the monitoring of heavy metal impacts, the early detection and prevention of related diseases, and the development of detoxification methods. This workshop will present the latest research and technologies to tackle these issues and share innovative strategies for mitigating health risks from heavy metals and emerging pollutants.
President:
NO.:1
Metabolism of chalcogen elements in animals
NO.:2
Serum metabolome associated with occupational multi-metal mixture exposure and ECG conduction disturbances in lead smelter workers
NO.:3
Hexavalent chromium alters diet-induced liver disease
NO.:4
Research on the toxicity and underlying mechanism of poorly soluble metal oxide nanomaterials
NO.:5
Lead contamination in African countries
NO.:6
Respiratory toxicity and biomarkers of chromates: Insights from multi-Omics analysis
NO.:7
Elucidating mechanisms of nickel carcinogenicity to ensure safe use through robust risk assessments
NO.:8
High-Throughput Technologies to Elucidate Effects of Heavy Metals on Early-Life Neuro development and Airway/Lung Maturation
Session 16: AI-empowered Environmental Computational Toxicology[Symposium Program （Session）]
The proposed symposium aims to explore the intersection of environmental science & engineering, computational toxicology, and artificial intelligence (AI). The symposium will bring together experts from academia, industry, and regulatory agencies to discuss the latest advancements, challenges, and opportunities in leveraging AI for understanding the impact of emerging pollutants on human and ecological health. The symposium focuses on the application of AI techniques in environmental computational toxicology, enabling the efficient prediction of the exposure, hazards, and risks of chemicals, and identification of emerging pollutants. Key topics to be addressed include the development of innovative computational models, integration of diverse data sources, and the use of advanced AI algorithms for chemical exposure, hazards, and risk assessment. It is also important to design and use green alternative chemicals to promote integrated social, economic, and environmental sustainability. Generative AI techniques are expected to propose innovative solutions for the design of green alternative chemicals, which remains a pivotal research topic in the symposium. Attendees will leave with interdisciplinary insights into the potential of AI-empowered environmental computational toxicology methodologies for safeguarding human and ecological health in the face of emerging pollutants, harnessing the collaboration for a sustainable world.
NO.:1
AI-empowered environmental computational toxicology on risk prediction and control of chemicals
NO.:2
Predictive models for ABC transporter inhibition and chemical efflux: Data collection, model development, and application for predicting chemical properties and toxicities
NO.:3
Unlocking safer futures: Computational toxicology models shaping next generation risk assessment (NGRA)
NO.:4
Modernizing environmental chemical risk assessment through an AI-Powered dose-response modeling system
Session 22: Thresholds of Toxicological Concern – Recent Developments across Regions and at the Interface with Computational Modelling[Symposium Program （Session）]
The PARC project (Partnership for the Assessment of Risks from Chemicals) aims to close data and knowledge gaps for priority compounds by developing NAM based assessments. The understanding of the absorption, distribution, metabolism and excretion of xenobiotic compounds a central assessment element in vitro to in vivo extrapolation and therefore of high importance for next generation risk assessment. Organised in four presentations, the symposium will provide insights into physiological based kinetic modelling approaches, which will evaluate the kinetic properties of Alternaria toxins and enniatins. To date, there are no PBK models for these emerging mycotoxins in any species. The talk will present a first modelling attempt using in vitro and in silico data (NAMS). It will discuss how bottom-up PBK modelling, as presented here, will facilitate the scientific community to adopt alternative ways to improve the assessment of ADME, whether common or specific to each of these toxins.
· Develop a tiered testing strategy for volatile compounds. Different in vitro barrier models will be compared to model their absorption within the different regions of the respiratory tract
· Assess the impact of the human microbiome on the biotransformation of chemicals and their uptake into the systemic circulation
Acknowledgement: The European Partnership for the Assessment of Risks from Chemicals has received funding from the European Union’s Horizon Europe research and innovation program under Grant Agreement No.101057014 and has received co-funding of the authors’ institutions.
President:
NO.:1
Application of TTC in food safety risk assessment in China
NO.:2
TTC based on plasma concentrations (internal TTC)
NO.:3
Development of TTC values for inhalable substances
NO.:4
Thresholds for skin sensitization
NO.:5
Application of the TTC concept to complex mixtures
Workshop 07: Strategic Assessment and Prioritization of Chemicals for Hazard and Risk Assessment[Workshop]
Governments and public health institutions especially in developing countries often need guidance and support in identifying and prioritizing chemicals and settings for risk assessment. Navigating the existing resources can be challenging, particularly when capacity is limited. The WHO Chemical Risk Assessment Network is developing and piloting a decision-making framework to help strengthen country capacity and infrastructure to identify, prioritize, and evaluate their chemical inventories for potential toxicity and risks to human health. The framework promotes existing tools and international mechanisms for chemicals management, in user-friendly and readily accessible formats, which promotes harmonization and reduces duplication of efforts. The framework was informed by a survey of the needs, tools and capacity of some developing country institutions within the Network. This session provides an overview of the framework, highlights the value in prioritizing chemicals and settings for risk assessment, and includes illustrative case studies and lessons learned from developed and developing countries. The case studies have assessed known and listed problematic compounds in the European Union, industrial chemicals, active pharmaceutic ingredients, pesticides, inorganic compounds, metals, organic compounds, highly toxic chemicals, and more, demonstrating wide applicability and utility. Prioritization frameworks based on health risks enable more cost-effective risk management and protection of public health.
NO.:1
A semi-quantitative risk-based prioritization scheme for chemicals of concern in Nordic countries
NO.:2
Multi-country regulatory data-driven hazard assessment for the prioritization of chemicals
NO.:3
Risk-based prioritization of chemicals
NO.:4
A tiered decision-making framework for identifying and prioritizing national chemical inventories for risk assessment
Workshop 08: Joining Forces towards the Human Exposome Project[Workshop]
Four decades after the Human Genome Project began, it is clear that genetics explains only a fraction of overall disease risk. The primary driver of health and disease is exposure—encompassing physicochemical, lifestyle, and environmental factors. However, a significant gap remains in the quantitative understanding of these influences. The Human Exposome Project aims to systematically explore and catalog these exposures, paralleling the genomic revolution in human biology. This initiative seeks to train a new generation of scientists dedicated to unraveling the complex environmental determinants of health. By fostering global collaboration, the project will unite researchers collecting exposome data, working toward a standardized framework to define the exposome and address critical knowledge and methodological gaps. This workshop will highlight the challenges in exposome research and outline the technological and conceptual advancements needed to drive the field forward. Through international cooperation, the Human Exposome Project has the potential to transform our understanding of disease causation and prevention, ultimately complementing genomic insights with a more holistic view of human health.
NO.:1
A call for a human exposome project
NO.:2
Recent advances in China national human biomonitoring and exposomics research
NO.:3
Rethinking health in the face of modern environmental risks: The role of exposomics
NO.:4
ExposomeX: Integrative exposomic platform expedites discovery of “exposure-biology-disease” nexus
NO.:5
Global harmonization for exposomics: Opportunities and challenges
Session 17: Toxicities From Traditional Pharmaceutical Drugs: New Insights Into the Mechanisms and Therapeutic Approaches[Symposium Program （Session）]
Pharmaceutical drugs used since decades still represent the only available therapeutic solutions to manage some major pathologies. Although their benefit has been largely established, they are still representing concerns with life-threatening poisonings and persistent gaps in the understanding of their mechanisms of toxicity. Acetaminophen, lithium, metformin, and local anaesthetics are the most important examples of such drugs. New insights in toxicity, development of new applications, and identification of potential new antidotes are susceptible to modify the management strategy of poisoned patients and offer some encouraging perspectives to improve outcome. The purpose of this symposium is 1- to update the mechanisms of toxicity of these various pharmaceuticals with a focus on the novel involved pathways; and 2- to present translational data from the bench to the bedside showing how experimental data may expand their therapeutic use while improving the safety of their administration and the outcome of intoxicated patients.
NO.:1
Acetaminophen toxicity: Role of the c-jun N-terminal kinase pathway and benefits of fomepizole
NO.:2
Metformin toxicity: Understanding mitochondria impairment and expanding therapeutic applications
NO.:3
Lithium toxicity: Understanding brain distribution variability to improve elimination
NO.:4
Local anaesthetics toxicity: Evidence and controversies on lipid emulsion
Session 23: Mechanisms of Immune System Toxicity and Therapeutic Approaches for Modifying Disease[Symposium Program （Session）]
The toxic effects of environmental and occupational exposure to particulate and fibrous matter, chemicals, and metals are global health problems, and it is necessary that immunotoxicity should be understood more, both as activation and suppression in immune response can lead to adverse health outcomes. In addition, elucidation of immune dynamics related to therapeutic responses for related diseases is also needed to guide appropriate treatment. Therefore, the Japanese Society of Toxicology proposes a symposium session with a theme focusing on molecular mechanisms of immune system toxicity induced by various materials and therapeutic approaches for modifying the related diseases on the basis of immunotoxicological knowledge. PFAS are highly bioaccumulating chemicals that induce immune suppression. Trichloroethylene is known for producing autoimmunity, sensitization, and allergy. Asbestos causes malignant mesothelioma, in which not only carcinogenicity but also immunotoxicity is involved. Particulate matter-induced inflammation in the lung and hypersensitivity responses involve an interesting mechanism of innate immunity. Arsenic is a typical metal that exhibits toxicity, but it is also known to be applied to treat malignant diseases related to immune responses. At this symposium, the latest findings will be explained by leading experts in each field.
NO.:1
Immune suppression by exposure to PFAS: Focus on B cell development and metabolism
NO.:2
Environmental pollutants as drivers of autoimmune disease
NO.:3
Immune signatures of asbestos exposure and mesothelioma: Biomarkers for asbestos-induced immune suppression and immunotherapy
NO.:4
Molecular machinery of particle-caused inflammation and allergy in lung immunity
NO.:5
Arsenic trioxide targeting Cys213 in PML-RARa protein to cure acute promyelocytic leukemia
Workshop 09: Protecting People & Planet: Integrating Human and Environmental Safety in Next Generation Risk Assessment (NGRA)[Workshop]
Unilever and the Committee of Toxicological Alternatives and Translational Toxicology (TATT) of the Chinese Society of Toxicology (CST) are co-hosting a workshop focused on next generation risk assessment (NGRA) frameworks for human and environmental health. The event brings together industry and academic experts to discuss integrating safety assessments using New Approach Methodologies (NAMs), such as computational models, in vitro systems, and omics technologies, without animal testing. Four talks are below
1. Dr. Bruno Campos (Unilever) will highlight strategies for bridging human and environmental NGRA, emphasising the value of mechanistic data and NAMS.
2. Professor Ping Xu’s session will present evidence that phosphoproteomics responds earlier and more sensitively to chemical exposure than proteomics and transcriptomics, correlating with the earliest biological impacts.
3. Professor Wei Shi will introduce RepTox, a computational tool utilising Adverse Outcome Pathways (AOPs) to predict reproductive toxicity, linking chemical features to physiological outcomes.
4. Dr. Yiping Xu will discuss an advanced fish PBTK model merged with in vitro–in vivo extrapolation (IVIVE), enhancing ecological risk assessment for endocrine-disrupting chemicals by predicting internal doses and species sensitivities.
The workshop also recognises the achievements of the 2025 CST Alternative Method Development Award recipients, Professor Ping Xu and Professor Wei Shi
NO.:1
Integrating Human and Environmental data streams to Support Safety Decisions.
NO.:2
Phosphoproteomics: A Cutting-Edge Tool for Analyzing Low-Dose Chemical Toxicity in NextGeneration Non-Animal Alternative Toxicology
NO.:3
Knowledge-Driven Artificial Intelligence as an Effective Approach to Overcome the “Black Box” Dilemma
NO.:4
PBTK-IVIVE-Enhanced Risk Assessment of EDCs Using In Vitro Effect Data
NO.:5
Next - Generation Risk Assessment (NGRA) Practice for Innovative Drugs via New Approach Methodologies (NAMs): Applying Alternative Methods in Preclinical Safety Evaluation
Workshop 10: Aquatic Organisms as Models for Toxicity Evaluation of Emergent Pollutants[Workshop]
Evaluation of toxicity has traditionally been performed using terrestrial vertebrate mammals such as rodents. However, aquatic organisms may also be used as experimental models and in fact, regulatory agencies throughout the world have implemented guidelines for environmental toxicity evaluation using sentinel species including invertebrates, fish, and algae.
Most, if not all, mechanisms of action observed in vertebrate mammals can also be studied in aquatic organisms making this a viable alternative for toxicity evaluation. Moreover, aquatic organisms may be advantageous over vertebrates due to easier and cheaper handling as well as taking up less living space and having shorter life spans.
In this continuing education course, we propose to teach about the advantages of using aquatic organisms for the study of toxicity and to discuss their application and limitations when used to predict toxicity to humans. We will share our experience in using these organisms, detailing laboratory set up and requirements for the maintenance of these species, including at least a rotifer (Brachionus plicatilis), crustaceans (ostracods and Daphnia magna), planarians (planarian spp), sea urchin (Paracentrotus lividus), clams (Corbicula fluminea), fish (Danio rerio, Oncorhynchus mykiss). We will exemplify their use to study emergent pollutants such as estrogenic compounds, pharmaceuticals, pesticides and micro and nanoplastics.
President:
NO.:1
Introduction to the use of aquatic species for toxicity evaluation
NO.:2
Study of the ecotoxic effect, development of PNEC and risk assessment of typical pollutants
NO.:3
Rotifers as experimental models for the study of estrogenicity
NO.:4
Evaluation of pharmaceutical compounds using sea urchins as model organisms
NO.:5
Neurological damage by DEHP in zebrafish and its epigenetic mechanism
NO.:6
Molecular biomarkers in fish as tools for environmental monitoring
NO.:7
The use of aquatic trophic chain to study the role of microplastics as vectors of pesticides
NO.:8
Potential ecological risks of reclaimed water: Insights into systemic stress and reproductive threats in earthworms revealed by Omics and physiological analyses
Session 18: Air Pollutants and PM2.5 - Chemical Composition and Health Consequences[Symposium Program （Session）]
Lung cancer is estimated to cause approximately 1.4 million cancer cases globally each year and has been the most common cancer in the world for more than two decades. Smoking and occupational exposure are known to contribute to an increase in lung cancer cases. Particulate matter pollution consists of a mixture of tiny solid and liquid droplets suspended in the air. These pollutants are composed of a variety of components, including SOx, NOx, NH3, organic chemicals, volatile metals, soil or dust particles, and allergens such as pollen or mold spores. Scientists have long believed there is a link between lung cancer and particulate matter pollution, specifically PM2.5. The environmental and health impacts of PM2.5 are an emerging research topic that require systematic research. However, the link between lung cancer and fine particulate pollution has not yet been studied in detail by many research institutions around the world. Therefore, ICT2025 is a good platform to discuss the linkage between PM2.5 and lung cancer.
President:
NO.:1
From air to cells: The genomic impact of environmental carcinogens
NO.:2
Air pollution and chronic obstructive pulmonary disease
NO.:3
Novel analytical and bio-analytical concepts for addressing the composition as well as the toxicological impact of airborne particulate matter (PM)
NO.:4
An exposome approach to evaluate the biological and health effects of air pollution: Evidence from multiple studies
NO.:5
Study on the Mechanism of Pulmonary Injury Caused by Inhalation Exposure to Microplastics and Risk Assessment for Occupational Populations
Session 24: Towards Next Generation Probabilistic Risk Assessment Propelled by Artificial Intelligence and Quantitative Mode-of-Action Ontologies[Symposium Program （Session）]
At present, risk assessment of chemicals copes with uncertainty of models and results as well as with information gaps. Traditional deterministic risk assessment tackles this flaw by using uncertainty factors, worst-case approaches and thresholds. Acknowledging uncertainty necessitates embracing probabilities and accepting the remaining risk. Probabilistic methods are set to characterize uncertainties, which in turn may improve decision-making. Actual assessments of uncertainty can be more realistic than worst-case scenarios and may allow less conservative safety margins. Furthermore, this may facilitate the ongoing transition from traditional animal-based methods towards animal-free and human-centered new approach methodologies as part of next generation risk assessment. Probabilistic risk assessment as such is not new. However, a number of tools and methods have become available in recent years, which allow to reignite and leverage probabilistic risk assessment. This actually defines the scope of the present symposium. The first presentation foresees an introduction to probabilistic risk assessment and will showcase the prominent role of artificial intelligence. The second presentation will demonstrate how using chemoinformatics can improve probabilistic risk assessment. The third presentation will discuss the generation and use of mode-of-action ontologies as mechanistic frameworks that support animal-free human hazard identification. The fourth presentation will present artificial intelligence models for (eco)toxicity prediction using the adverse outcome pathway framework. The fifth presentation will revolve around exposure assessment, including the application of physiologically based kinetic models as means to quantify mode-of-action ontologies. The gender-balanced speaker line-up consists of delegates from the US, Europe and Asia with various backgrounds as well as with academic and industrial affiliations, therefore introducing a 3Is (international, interdisciplinary and intersectoral) dimension in this symposium in addition to its focus on 3Rs (replacement, reduction and refinement of animal experimentation)
NO.:1
Probability is the very guide of life (Cicero, 106-43 B.C.) and of toxicology (2024+)
NO.:2
From uncertainty to clarity: Using chemoinformatics to improve probabilistic risk assessment
NO.:3
Mode-of-action ontologies as the basis for setting up animal-free test batteries for hazard identification: Liver toxicity as a case study
NO.:4
Explainable artificial intelligence models for (eco)toxicity prediction using the adverse outcome pathway framework
NO.:5
Linking in vitro concentrations, internal tissue concentrations and external exposure through physiologically-based models
Session 25: Novel Strategies for Safety Assessment: A Paradigm Shift for the Future[Symposium Program （Session）]
Emerging therapeutic modalities, such as bispecific antibodies, novel peptide drugs and advanced cell and gene therapies, with high specificity to human targets, often exhibit low cross-reactivity in traditional animal species and present with various complex challenges for safety assessment. At the same time, tremendous endeavors have been made to reduce, refine and replace animal experimentation (3Rs) in light of US modernization act and European Commission’s intent to phase out animal testing. All these necessitate the development of innovative safety assessment approaches. This symposium aims to provide an overview of these advancements and their potential impact. Topics include strategies to minimize the use of non-human primates in drug development, the use of transgenic animals, alternative approaches including Weight of Evidence (WoE), and special considerations for the safety assessment strategy of emerging modalities such as peptide therapeutics.
The convergence of these approaches enhances safety assessments, reduces time and cost in drug development, and leads to safer therapeutic options. This symposium of speakers from multinational pharmaceutical companies associated with R&D-Based Pharmaceutical Association Committee (RDPAC) provides a platform for experts to discuss challenges and opportunities, shaping the future of drug safety evaluation.
President:
NO.:1
Strategies to minimize the use of non-human primates in drug development
NO.:2
Transgenic animal models for safety assessment
NO.:3
Alternative approaches for safety assessment
NO.:4
Nonclinical Safety Assessment of Peptide Therapeutics
Session 26: Next Generation Risk Assessment[Symposium Program （Session）]
Traditional toxicity testing based on animal experiments has served its purpose reasonably well. Yet, in light of ethics, ever-improving methods, conceptual challenges such as mixtures and large research initiatives such as Tox21 or PARC there is strong scientific and societal pressure for a paradigm shift. Although complexity and performance of in vitro and in silico methods have seen considerable progress, the incorporation of the respective approaches into regulatory assessments remains challenging. This is not the least because former projects often fell short to address specific regulatory needs. In order to overcome this, the “European Partnership for the Assessment of Risks from Chemicals” (PARC) as well as the ASPIS cluster have addressed various challenges associated with innovating chemical risk assessment. In this session, speakers will report on progress from these EU initiatives, but also taken into consideration the global perspective, how NAMs could be used to address complex endpoints like developmental and reproductive toxicity (DART) or in risk assessment of complex toxins like microcystins.
President:
NO.:2
Using NGRA to analyse microcystin toxicity
NO.:3
The ASPIS Safety profiler Algorithm (ASPA)
NO.:4
Improving the EST for NGRA of DART substances
NO.:5
AI-Driven text mining and NLP for advancing AOP development in chemical risk assessment: A PARC Perspective
Conference Keynote Speech[Keynote Lecture]
NO.:1
Medical potential of cannabis and psychedelics: Policy, challenges and future direction.
NO.:2
Advancing Chemical Research in Toxicology: From Genotoxicity to Gut Microbial Metabolism
NO.:3
"Modern Toxicology" and “Poison Science” – An inseparable pair to sustain Modern Civilization
NO.:4
Taking global submissions to the next level
Session 27: Environmental Genotoxic Effects: DNA Damage Response and Cell Death Signaling[Symposium Program （Session）]
The genomic instability, with the feature of increasing accumulation of DNA damage and mutations, is an intrinsic risk hallmark of various human diseases such as cancer, tissues degenerations and aging. A series of environmental factors, e.g., ionizing radiation, genotoxic chemical agents, and virus can induce a broad type of DNA damage. In addition, the application of radiotherapy and chemotherapy in cancer treatment is typically based on the property of inducing nucleic genomic DNA and mitochondria DNA damage which trigger cell death signaling and other DNA damage responses. Obviously, understanding the broader role and functional mechanisms of DNA damage repair involved in organisms against the genotoxic is a basic and attractive area in toxicology as well as in cancer therapies. Raising novel hypothesis or theory bases for practice on the basis of previous scientists' findings would be important for future promising druggable emerging targets for either prevention purpose or cancer therapies. In this review, we first illustrate the timeline steps for the understanding the roles of DNA damage repair and damage sensing and signaling to cell death, then we summarize and discuss the mechanisms regarding DNA damage repair associated with targeted therapy or intervention, highlighting the specific proteins, e.g., DNA-PK complex and their post-translational modifications in promoting DNA repair and cellular DNA damage response.
NO.:1
Radiation exposure and DNA damage repair: Mechanism and application
NO.:2
DNA repair and subsequent cancer risk ——“Can DNA repair backfire?
NO.:3
Toxicological assessments based on intestine 3D organoids reveal environmental low-dose nanosized microplastics (NPs) exposure aggravates radiation-induced intestine injury
NO.:4
The mechanism of ECs-HSCs transition in bone marrow hematopoiesis repair after irradiation
NO.:5
Tetrahydrobiopterin metabolism in radiation-induced injuries: Preclinical studies and phase II trial
NO.:6
Evaluation of oxidative stress and genetic instability among residents near mobile phone base stations in Germany
NO.:7
The effect of whole abdominal FLASH irradiation on the histopathology changes in mice and its potential mechanisms
Session 28: RNA Dysregulations and Environmental Carcinogenesis[Symposium Program （Session）]
The discovery and characterization of non-coding RNAs (ncRNAs) challenged the central dogma of molecular biology, representing a breakthrough in our understanding of RNA biology and functions. The 2024 Nobel Prize in Physiology or Medicine was awarded to two scientists who discovered small regulatory noncoding RNAs known as microRNAs, signifying the importance of noncoding RNA research. With the completion of the Encyclopedia of DNA Elements (ENCODE) Project and advances in genomic sequencing technologies, it is now known that human genome is pervasively transcribed, and a large portion of human genome is transcribed as ncRNAs. Many studies demonstrated that RNA dysregulations including ncRNAs play important roles in the development and progression of many human diseases, especially cancer although the mechanisms have not been well understood. Many chemical carcinogens are common environmental and occupational pollutants and important etiological factors for cancer and many other diseases. The effects of environmental carcinogens on RNA expressions and functions are exciting research fields in toxicology. The goals of this symposium are to introduce current research on RNA dysregulations in the field of toxicology, and to discuss the role and mechanism of RNA dysregulations in environmental carcinogenesis. To achieve these goals, this symposium convenes a panel of outstanding environmental carcinogenesis researchers. This symposium will attract an expanded ICTXVII audience of environmental carcinogenesis and other toxicology researchers.
President:
NO.:1
Circular RNA dysregulation and epigenomic reprogramming by iAs in carcinogenesis
NO.:2
Long noncoding RNA ABHD11-AS1 up-regulation promotes hexavalent chromium carcinogenesis
NO.:3
Regulatory mechanisms of circular RNAs in carbon black nanoparticle-induced DNA damage and malignant transformation of human airway epithelial cells
NO.:4
Role of RNA m6A methylation dysregulation in arsenic and benzo(a)pyrene co-exposure-induced cell transformation and tumorigenesis
NO.:5
Mechanisms of environmental carcinogenesis: how hexavalent chromium induces DNA repair dysregulation targeting RNA and protein
Session 29: Environmental Toxicology on Micro- and Nano-particulate Pollutants[Symposium Program （Session）]
Emerging particulate pollutants, such as nanoparticles and microplastics, raise environmental health and safety concerns in the international society. Over the last two decades, great efforts have been made to generate knowledge on the toxicity potential of particulate pollutants through environmental monitoring, toxicity screening, mechanistic investigations, etc. The symposium aims to bring experts in the field to share their views on the environmental toxicology of particulate pollutants and to foster discussions on urgent scientific questions to address as well as future perspectives.
President:
NO.:1
Biotests and biosensors for the evaluation of ecosafety of novel (nano)materials
NO.:2
More than a gut feeling: the interplay between nanomaterials/advanced materials and the gut microbiome
NO.:3
High-throughput screening and safer-by-design and nanomaterials
NO.:4
Toxicology and health risks of particulate pollutants
NO.:5
The accumulation of micro-nano plastics in the intestines and their damage to the intestinal tract
Session 30: Genetic Toxicology, Stem Cell Toxicology and Nanotoxicology[Symposium Program （Session）]
This conference closely aligned with global advancements in genetic toxicology and nanotoxicology, industry demands, and talent cultivation, aims to promote the integration of novel concepts, knowledge, technologies, and methodologies from life science and other toxicology fields into both genetic toxicology and nanotoxicology research and management. Currently, genetic toxicology is at a pivotal stage of its development, still grappling with significant issues such as the quantitative evaluation of genomic damage and genetic toxicity, as well as the establishment of genetic toxicity evaluation norms for nanomaterials and biological drugs. Nanotoxicology, on the other hand, faces challenges related to the safety of nanomaterials, urgently requiring the exploration of toxic mechanisms, the establishment of evaluation norms, and ensuring the safe application of nanotechnology. These challenges can only be effectively addressed through multidisciplinary infiltration, integration, collaborative efforts, and coordinated development. To this end, the conference has invited renowned experts from cancer prevention and treatment, epigenetic toxicology, nanotoxicology, and various application fields to present and discuss the latest research progress, cutting-edge theories and technologies, and strategies for achieving interdisciplinary integration. This will foster complementarity among disciplines and pave the way for further advancements in the field.
President:
NO.:1
Innovative approaches to assessing pollutant toxicity: From stem cells to AI
NO.:2
Genotoxic and carcinogenic effects of metal nanoparticles
NO.:3
The study on dual effect of tumor radiosensitization and normal tissue radioprotection based on DNA damage and repair mechanism
NO.:4
Environmental toxicants induce unexplained miscarriage
NO.:5
Evaluation and regulation on the genotoxicity of drug Impurities
Session 31: Clinical Translation and Practice of Hepatic Toxicology[Symposium Program （Session）]
With the theme of "Clinical Translation and Practice of Toxicology", this session will deeply discuss the application of toxicology in clinical practice and its translation research from bench-to-beside. Experts throughout the world will discuss the transformation of in vitro toxicology to in vivo study, and basic research to clinical evaluation and at last regulatory approach. Additionally, the session will highlight on the application and significance of toxicology and toxicant analysis in clinical medicine. The session aims to promote the improvement of toxicological research methods and technologies, promote the expansion of the research scope of academic, industrial and clinical pharmacists, and provide safer and more effective drug treatment solutions for clinical practice.
President:
NO.:1
Challenges in drug-induced liver injury: Paving the way for precision medicine
NO.:2
DILI: Molecular biology to clinical application
NO.:3
Drug-induced liver injury in children: A nationwide cohort study from China
NO.:4
Why do microplastics aggravate cholestatic liver disease? The NLRP3-mediated intestinal barrier integrity damage matter
