Bio: Dr. Corie Ellison received a Ph.D. degree in Pharmacology and Toxicology from the School of Medicine and Biomedical Sciences at The State University of New York at Buffalo. He joined The Procter & Gamble Company in 2011 as a Toxicologist in the Global Product Stewardship organization and is currently a Principal Scientist in the Central Product Safety division. Dr. Ellison’s current research efforts are in the areas of pharmacokinetics (Absorption, Distribution, Metabolism and Excretion) and New Approach Methods, particularly in addressing how findings in these fields can improve human health risk assessment for chemicals. Dr. Ellison is currently a committee member for the National Academies of Science, Engineering and Medicine (NASEM) Board on Environmental Studies and Toxicology (BEST) as well as the Scientific Advisory Committee on Alternative Toxicological Methods (SACATM).

Abstract: One of the next steps in the continued evolution of the threshold of toxicological concern (TTC) is to develop this concept further so that it is representative of internal exposures. This refinement, termed internal TTC (iTTC), requires a significant amount of data and computational tools that can be used to convert the chemical specific external dose No Observable Adverse Effect Levels (NOAELs) in the TTC database to an estimated internal exposure for each chemical. Over the past several years, a project has been actively focused on developing iTTC values. A comprehensive literature review was conducted on 1,251 chemicals to gather in vivo and in vitro data related to metabolism and pharmacokinetics. Following this, in vitro studies on Caco-2 permeability and hepatocyte metabolism were performed for approximately 200 chemicals in a collaboration between the Research Institute for Fragrance Materials, Cosmetics Europe, and the American Chemistry Council Long-Range Research Initiative. The compiled in vivo and in vitro data on permeability, metabolism and pharmacokinetics were utilized in various kinetic modeling workflows, including top-down, middle-out and bottom-up approaches. This work bringing us closer towards establishing the final iTTC values.