ICT2025 - lUTOX 17th International Congress of Toxicology

Kansuda Wunjuntuk

Affiliation / Organization：

Kasetsart University

Biography：

I’m Associate Professor Kansuda Wunjuntuk, Ph.D., RD, a nutrition scientist and registered dietitian at Kasetsart University. My work bridges experimental nutrition, functional foods, and safety assessment. I lead projects on defatted rice bran for chemoprevention and quinoa-derived protein concentrates, integrating antioxidant/anti-inflammatory biology, gut microbiome readouts, and translational study design.

Alongside efficacy, I incorporate safety and quality gates throughout the pipeline. In our preclinical program, I oversee sub-chronic toxicity studies in rodent models to evaluate supplements, botanical extracts, and novel foods, monitoring clinical chemistry, histopathology, and relevant mechanistic biomarkers to inform risk–benefit profiles. I also contribute to research governance through service in human research ethics and animal-care oversight, ensuring rigor and compliance.

At the graduate level, I teach Food Toxicology (Master’s), as well as courses in advanced nutrition and research methods, and I regularly mentor students across laboratory and thesis work. Ultimately, I aim to de-risk innovation in functional nutrition—advancing food-based solutions that are not only effective but demonstrably safe, reproducible, and ready for real-world use.

Date	Time	Local Time	Room	Forum	Session	Role	Topic
2025-10-17	09:30-09:45	2025-10-17,09:30-09:45	Room A - Guojin Hall	Symposium Program （Session）	Young Scientist Lecture 01：Advances in Feed Safety and Toxicology: From Detection and Toxicological Evaluation to Risk Management and Control	Speaker	Defatted Rice Bran Attenuates Inflammation Index and Modulates Gut Microbiota–SCFAs Axis in Colitis-Associated Colorectal Cancer Colorectal cancer (CRC) is increasingly prevalent worldwide and is closely linked to chronic inflammation, dietary patterns, and changes in gut microbiota composition. Defatted rice bran (DRB), a by-product of producing rice bran oil, is rich in dietary fibre, proteins, vitamins, minerals, and bioactive compounds that may benefit gut health and modulate inflammation. This study aimed to investigate the chemopreventive effects of DRB on inflammation, gut microbiota, and short-chain fatty acid (SCFA) production in a rat model of colitis-associated CRC induced by azoxymethane/dextran sulphate sodium (AOM/DSS). Male Wistar rats were randomly assigned to four groups: Control, AOM/DSS-induced CRC, and two treatment groups receiving DRB at doses of 3 and 6 g/kg body weight daily for 90 days. Colonic inflammation was assessed by quantifying cytokines (IL-6, TNF-α, IL-10), and a composite inflammation index was calculated. Gut microbiota composition was evaluated using 16S rRNA sequencing, and SCFA concentrations were determined via gas chromatography. Statistical analyses included ANOVA, Spearman’s correlation, and multiple regression. DRB supplementation significantly reduced the composite inflammation index compared to the AOM/DSS control group (p<0.001). No significant difference was found between the 3 g/kg and 6 g/kg DRB dosages, indicating dose-independent anti-inflammatory effects. DRB positively modulated gut microbiota composition, increasing beneficial genera such as Lactobacillus and Enterorhabdus while decreasing inflammation-associated taxa. Significant negative correlations were observed between pro-inflammatory cytokines (IL-6, TNF-α) and beneficial SCFAs, particularly acetic and butyric acids, while IL-10 positively correlated with these SCFAs. Additionally, IL-6 and TNF-α exhibited opposing predictive effects on butyric acid concentrations, suggesting complex interactions between inflammation and microbial metabolites. These findings suggest that DRB may serve as a dietary strategy to mitigate inflammation-driven colorectal carcinogenesis through immunometabolic modulation of gut health.

Date

Time

Local Time

Room

Forum

Session

Role

Topic

2025-10-17

09:30-09:45

2025-10-17,09:30-09:45

Room A - Guojin Hall

Symposium Program （Session）

Young Scientist Lecture 01：Advances in Feed Safety and Toxicology: From Detection and Toxicological Evaluation to Risk Management and Control

Speaker

Defatted Rice Bran Attenuates Inflammation Index and Modulates Gut Microbiota–SCFAs Axis in Colitis-Associated Colorectal Cancer

Colorectal cancer (CRC) is increasingly prevalent worldwide and is closely linked to chronic inflammation, dietary patterns, and changes in gut microbiota composition. Defatted rice bran (DRB), a by-product of producing rice bran oil, is rich in dietary fibre, proteins, vitamins, minerals, and bioactive compounds that may benefit gut health and modulate inflammation. This study aimed to investigate the chemopreventive effects of DRB on inflammation, gut microbiota, and short-chain fatty acid (SCFA) production in a rat model of colitis-associated CRC induced by azoxymethane/dextran sulphate sodium (AOM/DSS). Male Wistar rats were randomly assigned to four groups: Control, AOM/DSS-induced CRC, and two treatment groups receiving DRB at doses of 3 and 6 g/kg body weight daily for 90 days. Colonic inflammation was assessed by quantifying cytokines (IL-6, TNF-α, IL-10), and a composite inflammation index was calculated. Gut microbiota composition was evaluated using 16S rRNA sequencing, and SCFA concentrations were determined via gas chromatography. Statistical analyses included ANOVA, Spearman’s correlation, and multiple regression. DRB supplementation significantly reduced the composite inflammation index compared to the AOM/DSS control group (p<0.001). No significant difference was found between the 3 g/kg and 6 g/kg DRB dosages, indicating dose-independent anti-inflammatory effects. DRB positively modulated gut microbiota composition, increasing beneficial genera such as Lactobacillus and Enterorhabdus while decreasing inflammation-associated taxa. Significant negative correlations were observed between pro-inflammatory cytokines (IL-6, TNF-α) and beneficial SCFAs, particularly acetic and butyric acids, while IL-10 positively correlated with these SCFAs. Additionally, IL-6 and TNF-α exhibited opposing predictive effects on butyric acid concentrations, suggesting complex interactions between inflammation and microbial metabolites. These findings suggest that DRB may serve as a dietary strategy to mitigate inflammation-driven colorectal carcinogenesis through immunometabolic modulation of gut health.