Bio: Dr. He is a research fellow at the Institute of High Energy Physics, Chinese Academy of Sciences, and currently addressing methodological challenges in the quantitative and metabolic research of nanomaterials while incorporating cutting-edge technologies such as nuclear analytical methods, synchrotron radiation techniques, nanoscale secondary ion mass spectrometry, laser ablation mass spectrometry imaging, and artificial intelligence. He has published over 80 papers in academic journals such as Nature-series journals, Angewandte Chemie, ACS Nano, Environmental Science & Technology, with more than 5,500 SCI citations and an H factor of 41. He was elected as an Outstanding Young Scientist of the Chinese Academy of Sciences and received the Outstanding Youth Science and Technology Award from the Chinese Society of Toxicology.

Abstract: The rapid development of nanotechnology and the widespread use of engineered nanoparticles (NPs) have raised concerns regarding their potential environmental and health risks, particularly due to improper use, disposal, or accidental release. In general, the fate and transport of NPs in both the environment and living organisms are primarily dictated by their physicochemical properties. However, these properties are not static—NPs can undergo biotransformation, dynamically altering their characteristics in response to microenvironmental conditions. Such transformations play a crucial role in shaping nano-bio interactions and determining toxicological outcomes. To elucidate the toxicological mechanisms of NPs—specifically, how their initial state and dynamic evolution determine their biological effects—it is essential to conduct in-depth investigations into their biotransformation. This presentation will showcase research utilizing synchrotron radiation and nuclear analytical techniques to probe nanoscale transformations occurring at the nano-bio interface and the subsequent impact on nano-bio interactions. These findings offer critical insights into the environmental fate and in vivo metabolism of NPs, contributing to a more comprehensive understanding of their potential risks and broader implications for nanotoxicology and environmental safety.