Bio: Seiichi Ishida has been Professor of Division of Applied Life Science, Graduate School of Engineering, Sojo University, and Guest Researcher of Biological Safety Research Centre at National Institute of Health Sciences since 2020. He received his PhD in Pharmaceutical Science from the University of Tokyo, Japan in 1993, and conducted postdoctoral studies at The Cancer Institute (Tokyo) and at Howard Hughes Medical Institute at Duke University Medical Centre. He used to be Senior Researcher (2000-2007) and Section Chief (2007-2020) of Division of Pharmacology at National Institute of Health Sciences. His research focuses primarily on the development of in vitro cell assay platform including MPS (microphysiological systems) for the evaluation of drug metabolism and drug induced liver injury and their application to the regulatory science field.

Board Member: International MPS Society (iMPSS), iMPSS Asia-Pacific Regional Chapter (Chair), The Japanese Society for Alternatives to Animal Experiments, Japan MPS Initiative (Chair)

Abstract: Efforts to implement microphysiological systems (MPS) in industry are flourishing. While MPS-related projects are being promoted by AMED (Japan Agency for Medical Research and Development) in Japan, various projects and suppliers are also promoting development worldwide. In this presentation, we will first overview these trends. 1,2) Based on this, the status of utilization of MPS in regulatory field will be reported, including Japan and overseas efforts. ‘Context of Use’ is important for the regulatory use of new test methods, and from this context, ‘points to consideration’ in MPS development can be derived. We would like to introduce specific examples 3) of such point and would like to have a discussion on the way to the regulatory acceptance of MPS.

1) Research and Development of Microphysiological Systems in Japan Supported by the AMED-MPS Project. Seiichi Ishida. Front. Toxicol. doi: 10.3389/ftox.2021.657765

2) Global Expansion of Microphysiological Systems (MPS) and Japan's Initiatives: Innovation in Pharmaceutical Development and Path to Regulatory Acceptance. Daiju Yamazaki, Seiichi Ishida. DMPK. doi:10.1016/j.dmpk.2024.101047

3) Enhanced Functionality of Human Hepatocytes using the Oxygen Permeable Culture Plate for Optimized Oxygen Supply in Co-culture Systems with Culture Inserts. Shoka Takebayashi, Kureha Suzuki et al. AATEX, 29, 64-74, 2024.