Bio: With over 17 years of experience in advanced research at L’Oreal, Dr Chunmei Ding specializes in developing in vitro cell and tissue models using multidisciplinary technologies and conducting related in vitro research and evaluations of cosmetic ingredients and finish products. She has led and participated in the establishment, standardized production, and application development of multiple three-dimensional reconstructed skin models in China.

Abstract: SkinEthicTM Reconstructed Human Epidermal (RHE) skin irritation method is an internationally accepted OECD test method used to detect the skin irritation properties of chemicals (OECD TG439). It has been showed to be robust and transferable.

SkinEthicTM Human Cornea Epithelium (HCE) Eye irritation test has been validated by the European Centre for the Validation of Alternative Methods (ECVAM) and was officially adopted into OECD TG492 in Oct 2017. This method can be used as a stand-alone test to predict UN GHS No Category (unclassified/non-irritant) chemicals. The SkinEthicTM HCE Time-to-Toxicity (TTT) assay, a multiple time-point exposure test method, has been validated by ECVAM and officially adopted into OECD TG492B in Jun 2022. This method is the first and currently the only OECD- adopted stand-alone in vitro test method which can distinguish between all three UN GHS categories for eye irritation. It allows for the complete replacement of the Draize rabbit eye test.

The global availability of the SkinEthicTM RHE and SkinEthicTM HCE models, as well as the above mentioned OCED adopted testing methods will be reviewed.