Bio: He is mainly engaged in the research of tumor radiation resistance mechanisms and the pathological mechanisms of FLASH radiotherapy, and has published more than 30 papers and obtained seven Chinese invention patents. He serves as an editorial board member of Radiation Medicine and Protection, a corresponding editorial board member of Chinese Journal of Radiation Medicine and Protection, and a reviewer of financial programs of the China Association for Science and Technology, among other academic positions.

Abstract: Radiotherapy, as one of the important methods for the treatment of malignant tumors, not only kills tumor cells, but also causes certain damage to the surrounding normal tissues, which will limit the effect of radiotherapy. Therefore, reducing the damage of radiotherapy to the surrounding normal tissues is currently the focus of radiation oncology research. Although intensity modulated radiotherapy and helical tomotherapy optimize the treatment ratio by dose fractionation strategy, their tissue protective effect is still limited by the physical dose distribution characteristics. In recent years, FLASH radiotherapy has shown breakthrough potential: preclinical studies have shown that it can reduce normal tissue toxicity under the premise of equivalent tumor control rate. However, its biological mechanism has not been fully elucidated, and is limited by lagging equipment development and lack of treatment parameter system. In view of the limitation that most of the existing studies are limited to short-term observation of a single organ, this study constructed a whole abdominal irradiation model, and systematically evaluate the dynamic changes of pathological damages in multiple organs from acute phase (3.5 days after irradiation) to medium and long term (3-6 months after irradiation), providing theoretical basis for the clinical application of FLASH radiotherapy.