Bio: Ph.D. Professor, Nanjing Medical University, Director of Science and Technology Department. She has won the award of Changjiang Scholars of the Ministry of Education, and National Science Foundation of China Outstanding Youth Fund. Her research interests are mainly focused on Environment and Health, especially the hazard of environmental dangerous factors or drugs to reproduction and development, lipid metabolism, inflammatory effect, and cardiovascular disease. Her group has published their research in journals including Leukemia, Nat Commum., Blood, BMC Med., and also won the second prize of the Natural Science Award of the Ministry of Education.

Abstract: Population studies have shown that exposure to metal mixtures is associated with craniosynostosis risk. Among these, the effect of nickel is particularly important. Exposure to nickel at the dose of human exposure during pregnancy can lead to premature closure of cranial sutures in offspring mice. Furthermore, evidence suggested that nickel promotes osteogenic differentiation of MSCs through lactate modification mediated by metabolic reprogramming and activation of the FGFR2-ERK pathway.