ICT2025 - lUTOX 17th International Congress of Toxicology

Date	Time	Local Time	Room	Forum	Session	Role	Topic
2025-10-17	14:40-14:50	2025-10-17,14:40-14:50	Room A - Guojin Hall	Symposium Program （Session）	Young Scientist Lecture 03：Artificial Intelligence Toxicology and New Technologies and Methods	Speaker	The repair effects and mechanisms of Gut microbiota-derived bile acids on radiation-induced intestinal injury Abstract: Background: The mechanism of occurrence and development of radiation-induced intestinal injury has not been fully illustrated. Intestinal flora and its metabolites are involved in the maintenance of intestinal epithelial barrier. Objective: To elucidate the role and mechanism of bile acid metabolism in the repair of radiation-induced intestinal injury. Methods: Bile acids were quantified by targeted metabolomics, the repairing effect of exogenous supplementation bile acids on radiation-induced intestinal injury was observed. In clinical pathological samples of patients with radiation enteritis, confirming the correlation between bile acid signaling and the expression of epithelial repair molecules. Results: The metabolic profile of bile acid in radiation enteritis was disturbed. Exogenous bile acid supplementation promoted the repair of radiation enteritis. There was a correlation between bile acid signal and the expression of repair and regeneration molecules in pathological samples of radiation enteritis patients. Conclusions: Bile acid metabolism disorder is involved in radiation-induced intestinal injury and its repair. Intervention of bile acid metabolism can promote the repair of radiation-induced intestinal injury.

Abstract: Background: The mechanism of occurrence and development of radiation-induced intestinal injury has not been fully illustrated. Intestinal flora and its metabolites are involved in the maintenance of intestinal epithelial barrier. Objective: To elucidate the role and mechanism of bile acid metabolism in the repair of radiation-induced intestinal injury. Methods: Bile acids were quantified by targeted metabolomics, the repairing effect of exogenous supplementation bile acids on radiation-induced intestinal injury was observed. In clinical pathological samples of patients with radiation enteritis, confirming the correlation between bile acid signaling and the expression of epithelial repair molecules. Results: The metabolic profile of bile acid in radiation enteritis was disturbed. Exogenous bile acid supplementation promoted the repair of radiation enteritis. There was a correlation between bile acid signal and the expression of repair and regeneration molecules in pathological samples of radiation enteritis patients. Conclusions: Bile acid metabolism disorder is involved in radiation-induced intestinal injury and its repair. Intervention of bile acid metabolism can promote the repair of radiation-induced intestinal injury.