Bio: Dr. Xiaoqing Chang is a Senior Predictive Toxicologist at Inotiv, where she provides scientific and technical support to the NTP Interagency Center for the Evaluation of Alternative Toxicological Methods (NICEATM) contract. Her primary effort is developing and applying computational approaches to evaluate new approach methodologies (NAMs) to establish their utility and confidence in toxicity testing and safety assessment. She is an expert in applying physiology-based kinetic models to facilitate in vitro to in vivo extrapolation (IVIVE) and has co-authored a number of publications on the topic. She also holds ABT certification and is a council member of the Biological Modeling Specialty Section of the American Society of Toxicology.

Abstract: The quantitative in vitro to in vivo extrapolation (IVIVE) translates in vitro activity concentrations to their equivalent in vivo doses, which can be used to establish reference doses. IVIVE plays an important role in promoting the use of New Approach Methodologies (NAMs) in chemical safety evaluation. A variety of tools with different levels of complexity have been developed to support IVIVE. One such tool was developed and provided under the U.S. National Toxicology Program’s Integrated Chemical Environment (ICE; https://ice.ntp.niehs.nih.gov/). ICE features open access to a large collection of curated in vivo, in vitro, and in silico data. It also provides a web-based, intuitive graphical user interface for various physiologically based toxicokinetic (PBTK) models included in the U.S. Environmental Protection Agency’s “httk” R package. The ICE IVIVE tool allows users to quickly generate in vivo equivalent administered doses (EADs) from corresponding in vitro data. During this presentation, participants will learn how to use the ICE IVIVE tool to build a query, generate EADs, view and interpret tabular and graphical output, and compare results to in vivo data or predicted human exposure data. Strategies for selecting in vitro data and PBTK models under different fit-for-purpose scenarios will also be discussed.