Bio: Dr. Chen focuses on the mechanisms of manganese neurotoxicity and its early intervention strategies. She has led two projects funded by the National Natural Science Foundation of China and one general project funded by the Beijing Natural Science Foundation. As a key researcher, she has participated in several major research programs, including the Major Research Plan of the National Natural Science Foundation and the Key Research and Development Program of the Ministry of Science and Technology. She is a recipient of the Beijing Outstanding Talent Project. Dr. Chen has published over 30 papers in journals such as Environment International and Environmental Pollution.

Abstract: Manganese (Mn) poisoning-induced neurodegeneration has been widely recognized as closely related to the pathogenesis of neurodegenerative diseases like Parkinson’s disease. The main objective of this study is to investigate the role of human nasal mucosal mesenchymal stem cells (hnMSCs) -derived small extracellular vesicles (sEVs) in Mn poisoning repair and explore their underlying mechanisms. The study designs various treatment strategies, including preconditioning or engineering approaches, to thoroughly examine the therapeutic effects and mechanisms of hnMSCs-sEVs in repairing Mn-induced neurotoxicity. To better understand the repair mechanisms of hnMSCs-sEVs in Mn toxicity, this study employs multi-omics analysis techniques to identify molecules and metabolites that play important roles in neuroprotection, anti-inflammation, and neurogenesis. By integrating these omics data, the research further reveals that hnMSCs-sEVs may exert repair effects through the regulation of multiple biological pathways, leading to the restoration of physiological homeostasis and the promotion of health recovery. In summary, this study demonstrates that hnMSCs-sEVs, as a multi-target and modifiable cell-based therapeutic strategy, can effectively repair Mn-induced neurotoxicity, significantly improving motor deficits and neural dysfunction. These findings provide new insights and therapeutic strategies for the treatment of Mn poisoning and neurodegenerative diseases in the future.