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Lun Song
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Beijing Institute of Basic Medical Sciences, China

Bio: Lun Song, Ph.D, Professor, Director of the Department of Stress Chronobiology, Beijing Institute of Basic Medical Sciences.

 

Education:

BS (1989) Jilin University, Changchun, Jilin, China

MS (1993) Beijing Institute of Basic Medical Sciences, Beijing, China

PhD (1997) Beijing Institute of Basic Medical Sciences, Beijing, China

Postdoctoral training (2004-2007) New York University

 

Research interests:

Signaling network involving in pathological responses induced by environmental stressors (UV, heavy mental, PM2.5, hypoxia, cold, heat, irradiation, microwave, etc)

 

Abstract: Endoplasmic reticulum (ER) stress-coupling autophagy is one the most important protective mechanism for cells to relieve ER stress and resist injury. In this study, we found that PERK, one of the ER sensor proteins, exerted a pro-survival role in arsenite-induced apoptotic responses by inducing cytoprotective autophagy. Most importantly, PERK promoted autophagy by inducting the activation of p53/DRAM1-dependent pathway. Further investigation disclosed that PERK functioned as a novel protein kinase for p53, therefore constituted the cytoprotective “PERK-p53-autophagy” signaling axis. In addition, nuclear translocation was required for PERK to be activated, which was also critical for inducing p53 activation upon arsenite exposure. Further investigation identified a novel PERK-interacting protein, ISG20L1, functioned as a regulator for nucleus translocation of PERK and "PERK-p53-autophagy" pathway activation after arsenite exposure. Subsequent studies further revealed that ISG20L1-PERK-p53-autophagy cascade activation was a common signaling event in mediating cancer cell apoptosis induced by arsenite and other tumor therapeutic agents. Since ISG20L1 is a well-known p53 downstream target and PERK is identified as an ER protein kinase in the previous reports, data in the current study thus have revealed the novel functions of ISG20L1 and PERK in coupling p53-dependent autophagy and their contribution to mediating cancer cell apoptosis.


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Date Time Local Time Room Forum Session Role Topic
2025-10-17 17:30-17:45 2025-10-17,17:30-17:45Room 2 - Guobin Hall 2 Workshop

Workshop 04: Heavy Metal Toxicity and Human Health-2

Speaker ER sensor protein PERK-coupled autophagy protects the cells from arsenite-induced apoptosis