Bio: Dr. Wang is an internationally renowned expert in nanotoxicology and nanomedicine. With over 20 years of pioneering research in nanotoxicology and nanomedicine, he has achieved remarkable breakthroughs that have garnered global recognition. His multidisciplinary research encompasses diverse nanomaterials, including carbonaceous, silicon-based, rare earth oxide, and metallic nanomaterials, with investigations of over 500 different types of materials varying in size, shape, and structure, etc. Recently, his has led to develop innovative "molecule-targeted drug delivery systems" for treating allergies, autoimmune diseases, genetic disorders and cancer. Professor Wang has published nearly 150 papers in prestigious journals including Nature Communications, Nano Today, and ACS Nano, etc., accumulating over 18,800 citations. His research impact is reflected in his H-index of 62 and i10-index of 113.

Abstract: The proliferation of electronic cigarettes (e-cigarettes), particularly among adolescents, has precipitated significant public health concerns regarding their potential adverse effects. While JUUL and Tank devices represent prevalent e-cigarette variants delivering aerosolized nicotine in diverse concentrations and flavors, the differential characteristics of their aerosols and subsequent biological impacts remain inadequately characterized. This investigation elucidates these knowledge gaps by analyzing aerosol properties and their corresponding cytotoxic and pulmonary effects. Our study reveals that the 3.7 V JUUL device, operating at lower voltage, generates 2.72 mg/puff aerosols utilizing 3% nicotine salt (nicotine benzoate), whereas the 7.5 V Tank device produces 11.06 mg/puff aerosols with 2.4% freebase nicotine. Notably, despite lower aerosol mass, JUUL-generated aerosols exhibited enhanced cytotoxicity and elevated pro-inflammatory cytokine production compared to Tank aerosols per puff. Furthermore, in vivo studies demonstrated that JUUL induced more severe pulmonary inflammation and DNA damage after cotinine normalization. These findings suggest that device architecture, rather than e-liquid composition or voltage, predominantly influences aerosol-induced toxicity. This research provides critical insights into device-specific health risks and establishes a framework for comprehensive e-cigarette evaluation.