Bio: I am a China fellow of the Yale-China Association. My research program has two main areas fueled by extramural funding. First, my team aims to understand the influence of environmental and occupational exposure of ionizing radiation and dust on lung. The ultimate goal of these research projects is to understand the underlying mechanisms how the roles of non-coding RNA in the regulation of genes and proteins. My second major area of research interest involves the formation of interdisciplinary teams to work with Yale-China Association to promote early health development of left-behind children and their families, particularly those of minority population in the very low-income areas in China. These efforts incorporate undergraduate and graduate student research and investigate the effectiveness of evidence-based interventions to improve healthiness for cognitive delayed prevention. I received several awards for excellence in teaching, research, and service. She is now on the council of the Asia Society of Toxicology.
Abstract: Here, we reported that development of intestinal organoids could be used to explore the toxicology mechanism for combination effects of low dose nanoplastic (NPs) chronic exposure and acute radiation on intestine injury, the two classical chemical and physical substances. First, through in vivo study, we found low dose NPs exposure could aggravate acute radiation-induced intestine injury including exacerbating damaged intestinal epithelial structure, shortened and fractured intestinal villi. Second, using an intestinal organoid model, we observed that low-dose NPs reduced radiation-induced proliferation and exacerbated inflammatory damage, which promoted inflammatory damage through elevated TGF-β1 expression, increased Smad3 phosphorylation, and diminished Smad7 expression. Furthermore, low-dose nanoplastics enhance radiation-induced intestinal damage via activation of the TGF-β1/p-Smad3 signaling pathway. This study demonstrates that low-dose NPs may exacerbate the radiation-induced intestinal damage and inflammation process in vivo and in vitro. Our study highlights, for the first time, the potential for intestine organoids serving as powerful tool for explore the combination effects of two chemical and physical substances in toxicology investigation.
15
0
0
Date | Time | Local Time | Room | Forum | Session | Role | Topic |
---|---|---|---|---|---|---|---|
2025-10-18 | 13:40-14:00 | 2025-10-18,13:40-14:00 | Room 1- Guobin Hall 1 | Symposium Program (Session) |
Session 27: Environmental Genotoxic Effects: DNA Damage Response and Cell Death Signaling |
Speaker | Toxicological assessments based on intestine 3D organoids reveal environmental low-dose nanosized microplastics (NPs) exposure aggravates radiation-induced intestine injury |