Bio: Dr. Zhangjian Chen is an assistant professor, associate researcher, and doctoral supervisor at the School of Public Health at Peking University. The main research areas are nanotoxicology and occupational health. Multiple studies have been conducted in the safety evaluation of nanomaterials. He led and participated in multiple national research projects, including the National Natural Science Youth Fund and the National Key R&D Program. He has published more than 30 papers as the first author or corresponding author in high-quality journals in the field, such as Particle and Fibre Toxicology, Nanoscale, etc. At present, he is a member of the Biomarkers Professional Committee of the Chinese Environmental Mutagen Society, and a youth member of the Toxicity Testing Alternatives and Translational Toxicology Professional Committee of the Chinese Society of Toxicology.

Abstract: Poorly soluble metal oxide nanomaterials are the most abundant and widely used type of nanomaterials, with nano titanium dioxide as a typical representative. At conventional scales, poorly soluble metal oxide coarse particles are generally relatively inert and low toxic. However, research has found that at the nanoscale, metal oxide nanoparticles with the same chemical composition are more likely to induce toxic effects than coarse particles. Therefore, the safety of poorly soluble metal oxide nanomaterials requires attention. We have conducted a series of studies on the genetic toxicity, cardiovascular toxicity, liver toxicity, and related toxicity mechanisms of nano titanium dioxide, combining high-throughput methods such as multi omics techniques to explore key toxicity pathways or biomarkers.