Session 17: Toxicities From Traditional Pharmaceutical Drugs: New Insights Into the Mechanisms and Therapeutic Approaches[Symposium Program （Session）]
Pharmaceutical drugs used since decades still represent the only available therapeutic solutions to manage some major pathologies. Although their benefit has been largely established, they are still representing concerns with life-threatening poisonings and persistent gaps in the understanding of their mechanisms of toxicity. Acetaminophen, lithium, metformin, and local anaesthetics are the most important examples of such drugs. New insights in toxicity, development of new applications, and identification of potential new antidotes are susceptible to modify the management strategy of poisoned patients and offer some encouraging perspectives to improve outcome. The purpose of this symposium is 1- to update the mechanisms of toxicity of these various pharmaceuticals with a focus on the novel involved pathways; and 2- to present translational data from the bench to the bedside showing how experimental data may expand their therapeutic use while improving the safety of their administration and the outcome of intoxicated patients.
NO.:1
Acetaminophen toxicity: Role of the c-jun N-terminal kinase pathway and benefits of fomepizole
NO.:2
Metformin toxicity: Understanding mitochondria impairment and expanding therapeutic applications
NO.:3
Lithium toxicity: Understanding brain distribution variability to improve elimination
NO.:4
Local anaesthetics toxicity: Evidence and controversies on lipid emulsion
Session 23: Mechanisms of Immune System Toxicity and Therapeutic Approaches for Modifying Disease[Symposium Program （Session）]
The toxic effects of environmental and occupational exposure to particulate and fibrous matter, chemicals, and metals are global health problems, and it is necessary that immunotoxicity should be understood more, both as activation and suppression in immune response can lead to adverse health outcomes. In addition, elucidation of immune dynamics related to therapeutic responses for related diseases is also needed to guide appropriate treatment. Therefore, the Japanese Society of Toxicology proposes a symposium session with a theme focusing on molecular mechanisms of immune system toxicity induced by various materials and therapeutic approaches for modifying the related diseases on the basis of immunotoxicological knowledge. PFAS are highly bioaccumulating chemicals that induce immune suppression. Trichloroethylene is known for producing autoimmunity, sensitization, and allergy. Asbestos causes malignant mesothelioma, in which not only carcinogenicity but also immunotoxicity is involved. Particulate matter-induced inflammation in the lung and hypersensitivity responses involve an interesting mechanism of innate immunity. Arsenic is a typical metal that exhibits toxicity, but it is also known to be applied to treat malignant diseases related to immune responses. At this symposium, the latest findings will be explained by leading experts in each field.
NO.:1
Immune suppression by exposure to PFAS: Focus on B cell development and metabolism
NO.:2
Environmental pollutants as drivers of autoimmune disease
NO.:3
Immune signatures of asbestos exposure and mesothelioma: Biomarkers for asbestos-induced immune suppression and immunotherapy
NO.:4
Molecular machinery of particle-caused inflammation and allergy in lung immunity
NO.:5
Arsenic trioxide targeting Cys213 in PML-RARa protein to cure acute promyelocytic leukemia
Workshop 09: Protecting People & Planet: Integrating Human and Environmental Safety in Next Generation Risk Assessment (NGRA)[Workshop]
Unilever and the Committee of Toxicological Alternatives and Translational Toxicology (TATT) of the Chinese Society of Toxicology (CST) are co-hosting a workshop focused on next generation risk assessment (NGRA) frameworks for human and environmental health. The event brings together industry and academic experts to discuss integrating safety assessments using New Approach Methodologies (NAMs), such as computational models, in vitro systems, and omics technologies, without animal testing. Four talks are below
1. Dr. Bruno Campos (Unilever) will highlight strategies for bridging human and environmental NGRA, emphasising the value of mechanistic data and NAMS.
2. Professor Ping Xu’s session will present evidence that phosphoproteomics responds earlier and more sensitively to chemical exposure than proteomics and transcriptomics, correlating with the earliest biological impacts.
3. Professor Wei Shi will introduce RepTox, a computational tool utilising Adverse Outcome Pathways (AOPs) to predict reproductive toxicity, linking chemical features to physiological outcomes.
4. Dr. Yiping Xu will discuss an advanced fish PBTK model merged with in vitro–in vivo extrapolation (IVIVE), enhancing ecological risk assessment for endocrine-disrupting chemicals by predicting internal doses and species sensitivities.
The workshop also recognises the achievements of the 2025 CST Alternative Method Development Award recipients, Professor Ping Xu and Professor Wei Shi
NO.:1
Integrating Human and Environmental data streams to Support Safety Decisions.
NO.:2
Phosphoproteomics: A Cutting-Edge Tool for Analyzing Low-Dose Chemical Toxicity in NextGeneration Non-Animal Alternative Toxicology
NO.:3
Knowledge-Driven Artificial Intelligence as an Effective Approach to Overcome the “Black Box” Dilemma
NO.:4
PBTK-IVIVE-Enhanced Risk Assessment of EDCs Using In Vitro Effect Data
NO.:5
Next - Generation Risk Assessment (NGRA) Practice for Innovative Drugs via New Approach Methodologies (NAMs): Applying Alternative Methods in Preclinical Safety Evaluation
Workshop 10: Aquatic Organisms as Models for Toxicity Evaluation of Emergent Pollutants[Workshop]
Evaluation of toxicity has traditionally been performed using terrestrial vertebrate mammals such as rodents. However, aquatic organisms may also be used as experimental models and in fact, regulatory agencies throughout the world have implemented guidelines for environmental toxicity evaluation using sentinel species including invertebrates, fish, and algae.
Most, if not all, mechanisms of action observed in vertebrate mammals can also be studied in aquatic organisms making this a viable alternative for toxicity evaluation. Moreover, aquatic organisms may be advantageous over vertebrates due to easier and cheaper handling as well as taking up less living space and having shorter life spans.
In this continuing education course, we propose to teach about the advantages of using aquatic organisms for the study of toxicity and to discuss their application and limitations when used to predict toxicity to humans. We will share our experience in using these organisms, detailing laboratory set up and requirements for the maintenance of these species, including at least a rotifer (Brachionus plicatilis), crustaceans (ostracods and Daphnia magna), planarians (planarian spp), sea urchin (Paracentrotus lividus), clams (Corbicula fluminea), fish (Danio rerio, Oncorhynchus mykiss). We will exemplify their use to study emergent pollutants such as estrogenic compounds, pharmaceuticals, pesticides and micro and nanoplastics.
President:
NO.:1
Introduction to the use of aquatic species for toxicity evaluation
NO.:2
Study of the ecotoxic effect, development of PNEC and risk assessment of typical pollutants
NO.:3
Rotifers as experimental models for the study of estrogenicity
NO.:4
Evaluation of pharmaceutical compounds using sea urchins as model organisms
NO.:5
Neurological damage by DEHP in zebrafish and its epigenetic mechanism
NO.:6
Molecular biomarkers in fish as tools for environmental monitoring
NO.:7
The use of aquatic trophic chain to study the role of microplastics as vectors of pesticides
NO.:8
Potential ecological risks of reclaimed water: Insights into systemic stress and reproductive threats in earthworms revealed by Omics and physiological analyses
