Session 27: Environmental Genotoxic Effects: DNA Damage Response and Cell Death Signaling[Symposium Program （Session）]
The genomic instability, with the feature of increasing accumulation of DNA damage and mutations, is an intrinsic risk hallmark of various human diseases such as cancer, tissues degenerations and aging. A series of environmental factors, e.g., ionizing radiation, genotoxic chemical agents, and virus can induce a broad type of DNA damage. In addition, the application of radiotherapy and chemotherapy in cancer treatment is typically based on the property of inducing nucleic genomic DNA and mitochondria DNA damage which trigger cell death signaling and other DNA damage responses. Obviously, understanding the broader role and functional mechanisms of DNA damage repair involved in organisms against the genotoxic is a basic and attractive area in toxicology as well as in cancer therapies. Raising novel hypothesis or theory bases for practice on the basis of previous scientists' findings would be important for future promising druggable emerging targets for either prevention purpose or cancer therapies. In this review, we first illustrate the timeline steps for the understanding the roles of DNA damage repair and damage sensing and signaling to cell death, then we summarize and discuss the mechanisms regarding DNA damage repair associated with targeted therapy or intervention, highlighting the specific proteins, e.g., DNA-PK complex and their post-translational modifications in promoting DNA repair and cellular DNA damage response.
NO.:1
Radiation exposure and DNA damage repair: Mechanism and application
NO.:2
DNA repair and subsequent cancer risk ——“Can DNA repair backfire?
NO.:3
Toxicological assessments based on intestine 3D organoids reveal environmental low-dose nanosized microplastics (NPs) exposure aggravates radiation-induced intestine injury
NO.:4
The mechanism of ECs-HSCs transition in bone marrow hematopoiesis repair after irradiation
NO.:5
Tetrahydrobiopterin metabolism in radiation-induced injuries: Preclinical studies and phase II trial
NO.:6
Evaluation of oxidative stress and genetic instability among residents near mobile phone base stations in Germany
NO.:7
The effect of whole abdominal FLASH irradiation on the histopathology changes in mice and its potential mechanisms
