Session 13: Mapping Human Immune Development and New Approach Methodologies to Test Its Vulnerability to Toxicants[Symposium Program （Session）]
Interest in developmental immunotoxicity (DIT) has grown due to the rise in immune-mediated developmental disorders in children linked to environmental exposures. The developing immune system is particularly sensitive to chemical and environmental stressors during critical prenatal and postnatal periods, leading to long-term dysfunction. Understanding age-related vulnerability to immunotoxicants is crucial. Recent advances have filled critical knowledge gaps about the developing immune system. Efforts to map human immune development using high-dimensional cytometry, single-cell RNA sequencing, antigen-receptor sequencing, and spatial transcriptomics have provided valuable insights. Immune mapping from infancy to early adulthood has enhanced our understanding of how aging influences immune responses and disease susceptibility. Such human immune cell atlas is also vital for investigating DIT risk. Traditionally, DIT risk assessments relied on animal models, with limited endpoints and developmental windows, and limitations in scalability, high-throughput, and human translatability. Developing predictive NAMs is essential to better understand DIT and for evaluating more chemicals across a broader range of biological effects in a shorter timeframe with fewer resources. This session will convene immunologists and toxicologists to discuss the latest advances in human immune mapping, challenges in developing precise, predictive, and translatable NAMs for DIT, and explore examples with high potential for regulatory screening.
President:
NO.:1
Developmental immunotoxicity testing: Challenging the status quo
NO.:2
An immune map of human body across ages and sexes based on single-cell deconvolution
NO.:3
Microfluidic models of human bone marrow and lymph node for immunotoxicity studies
NO.:4
Human umbilical cord blood derived CD34+ hematopoietic stem cells as an in vitro model for investigating developmental immunotoxicity
Session 19: Assessing the Exposure and Toxicity of Emerging Toxicants in Humans[Symposium Program （Session）]
Emerging toxicants encompass chemical substances recently identified as potentially harmful to human health or the environment yet not extensively studied or regulated. These substances include microplastics, nanomaterials, per- and poly-fluoroalkyl substances (PFAS), pharmaceutical drugs, pesticides, personal care products, and other compounds. Monitoring and researching these substances are crucial to better understand their effects and develop appropriate regulations to protect public health and the environment. This symposium aims to underscore the critical importance of assessing exposure and health effects of emerging toxicants in human populations. As our environment evolves, new substances emerge, posing challenges to toxicological evaluation. This symposium will convene leading experts to delve into innovative methodologies and state-of-the-art research focusing on human population exposure assessment and associated health effects of emerging toxicants. Topics will encompass advancements in biomonitoring techniques, identification of novel toxicants, exploring toxicant exposure levels in different populations, and assessing the impact of toxicants on human health through population-based studies or human subjects’ research. By fostering collaboration and knowledge exchange, this symposium seeks to deepen our understanding of emerging toxicants' impacts on human health and inform strategies for mitigating associated risks.
NO.:1
Old and new insights in the respiratory toxicity of carbon-based nanomaterials
NO.:2
Children's third-hand smoke exposure assessment
NO.:3
Rethinking health in the face of modern environmental risks: The role of exposomics
NO.:4
Leveraging pulmonary nanotoxicological discoveries for the design of inhalable nanotherapeutics
NO.:5
Toxicity of electronic cigarette aerosols
Workshop 01: Drug Toxicology and Drug Safety Evaluation[Workshop]
This seminar focuses on the specialized topics of Drug toxicology and drug safety evaluation, featuring senior pharmacotoxicology experts from China and the United States, as well as professors with extensive research experience in multinational pharmaceutical companies. The event aims to analyze and discuss current hotspots and challenges in pharmacotoxicology research. Through presentations by leading experts from both China and the U.S., attendees engaged in pharmacotoxicology and non-clinical evaluation studies will gain substantial insights and inspiration to advance their work.
NO.:1
Developing Non-Clinical Safety Assessment Strategy for New Drug Development
NO.:2
Special considerations in conducting an enhanced pre- and postnatal development (ePPND) study in cynomolgus monkeys of biotherapeutics
NO.:3
Key considerations and case studies in non-clinical research of cell therapy products for solid tumors
NO.:4
Nonclinical safety strategies for cancer immunotherapies
NO.:5
Workshop 02: Application of Synchrotron Radiation Techniques in Toxicology[Workshop]
Synchrotron radiation (SR) combines high brightness, a broad energy spectrum, and tunable wavelengths, positioning it as a powerful and indispensable tool in scientific research. In the field of toxicology, SR techniques have been increasingly employed to investigate the behavior and effects of various toxic substances at the molecular and cellular levels. This workshop is designed to introduce the diverse characteristics and advantages of SR techniques and their growing applications in toxicology. By bringing together beamline experts and toxicologists, we aim to demonstrate how SR techniques can deepen our understanding of the mechanisms and effects of toxicants, particularly emerging pollutants, which present novel challenges to environmental and public health. The workshop will also introduce cutting-edge SR techniques and examine their potential applications in toxicology. Moreover, we will discuss the integration of SR data with other analytical methodologies to create a more comprehensive framework for understanding toxicological phenomena. Ultimately, this workshop seeks to stimulate interdisciplinary collaborations, inspire innovative approaches, and contribute to advancing the science of toxicology. By leveraging SR techniques, we aim to enhance our ability to assess and mitigate the risks posed by toxic substances, ultimately benefiting public health and environmental safety.
President:
NO.:1
Nanoscopic X-ray analytical techniques with synchrotron radiation to assess toxicity mechanisms of metals and nanomaterials in ecosystems
NO.:2
Synchrotron radiation-based characterization of nanomaterial biotransformation: Environmental degradation and in vivo metabolism
NO.:3
Applications of synchrotron-based scanning transmission X-ray microscopy in toxicology
NO.:4
Synchrotron-based X-ray microscopy for cell imaging
NO.:5
X-ray investigation for aqueous – biomembrane interfaces at the beamline P08 of PETRA III
NO.:6
Synchrotron radiation- and MS-based analysis of nano-bio interface: Composition, structure, and effects
