CEC01: Advancing Scientific Excellence and Increasing Confidence in NAMs Through Good In Vitro Method Practices (GIVIMP)[Continuing Education Courses (CEC)]
The landscape of pre-clinical testing is shifting with the introduction of novel test systems like microphysiological systems and other cell-based models, instead of relying on animal models. In response to regulatory imperatives for transitioning to these human-relevant models, scientists are turning to the development and routine use of New Approach Methodologies (NAMs). This continuing education course is designed to acquaint professionals with the principles and practices outlined in the OECD guidance document 286 – Good In Vitro Method Practices (GIVIMP). Starting with an exploration of the foundational principles shaping GIVIMP, the course emphasizes its role not only in ensuring high standards for study performance but also in influencing the design and development of NAMs. Participants will be presented with a summary of topics such as roles and responsibilities; facility design; apparatus, materials, and reagents; test systems; standard operating procedures; and the recording and reporting of results. The course illustrates the integration of GIVIMP recommendations into a variety of laboratory settings through the use of several case studies. The overarching goal is to empower scientists with the knowledge and tools essential for navigating the intricacies of in vitro methods, thereby upholding the highest standards of quality and reliability across diverse laboratory settings.
President:
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Founding principles of GIVIMP
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Good In Vitro method practices (GIVIMP) overview
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Test System Strategies: Applying GIVIMP to Improve NAMs
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Taking advantage of GIVIMP during method development
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Applying GIVIMP in a Respiratory Laboratory
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Application of GIVIMP principles to a laboratory in China
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Impact of increased confidence in NAMs on acceptance in China and beyond
CEC04: Episkin Academy Training[Continuing Education Courses (CEC)]
Episkin Academy Training is a course that gives attendees a tour of reconstructed tissue models and covers the best ways to use them in applications and validated methods. Attendees will have the opportunity to realize by themselves skin and eye irritation tests with unknown products. The course is taught by highly experienced scientists from L’OREAL and includes lectures (inspired by OECD guidelines (TG431, TG439, TG492), SOPs) and hands-on exercises that provide real-world experience. It will also integrate an introduction on next-generation risk assessment process (NGRA), which is an exposure-led, hypothesis-driven risk assessment approach that integrates existing knowledge with in silico, in chemico, and in vitro approaches. Particpants will have an overview of each step of next-generation risk assessment process (NGRA) applied on cosmetics safety.
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The integration of new methods and approaches in the safety assessment of cosmetic ingredients in Europe in the context of animal testing ban
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Overview of Integrated Approaches to Testing and Assessment (IATA) process and its application in regulatory toxicology
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methodology for eye hazard identification validated by OECD
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On site operation demonstration and hands on training of SkinEthic™ RHE irritation & corrosion testing and SkinEthic™ HCE eye irritation testing
