Session 16: AI-empowered Environmental Computational Toxicology[Symposium Program （Session）]
The proposed symposium aims to explore the intersection of environmental science & engineering, computational toxicology, and artificial intelligence (AI). The symposium will bring together experts from academia, industry, and regulatory agencies to discuss the latest advancements, challenges, and opportunities in leveraging AI for understanding the impact of emerging pollutants on human and ecological health. The symposium focuses on the application of AI techniques in environmental computational toxicology, enabling the efficient prediction of the exposure, hazards, and risks of chemicals, and identification of emerging pollutants. Key topics to be addressed include the development of innovative computational models, integration of diverse data sources, and the use of advanced AI algorithms for chemical exposure, hazards, and risk assessment. It is also important to design and use green alternative chemicals to promote integrated social, economic, and environmental sustainability. Generative AI techniques are expected to propose innovative solutions for the design of green alternative chemicals, which remains a pivotal research topic in the symposium. Attendees will leave with interdisciplinary insights into the potential of AI-empowered environmental computational toxicology methodologies for safeguarding human and ecological health in the face of emerging pollutants, harnessing the collaboration for a sustainable world.
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AI-empowered environmental computational toxicology on risk prediction and control of chemicals
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Predictive models for ABC transporter inhibition and chemical efflux: Data collection, model development, and application for predicting chemical properties and toxicities
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Unlocking safer futures: Computational toxicology models shaping next generation risk assessment (NGRA)
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Modernizing environmental chemical risk assessment through an AI-Powered dose-response modeling system
Session 22: Thresholds of Toxicological Concern – Recent Developments across Regions and at the Interface with Computational Modelling[Symposium Program （Session）]
The PARC project (Partnership for the Assessment of Risks from Chemicals) aims to close data and knowledge gaps for priority compounds by developing NAM based assessments. The understanding of the absorption, distribution, metabolism and excretion of xenobiotic compounds a central assessment element in vitro to in vivo extrapolation and therefore of high importance for next generation risk assessment. Organised in four presentations, the symposium will provide insights into physiological based kinetic modelling approaches, which will evaluate the kinetic properties of Alternaria toxins and enniatins. To date, there are no PBK models for these emerging mycotoxins in any species. The talk will present a first modelling attempt using in vitro and in silico data (NAMS). It will discuss how bottom-up PBK modelling, as presented here, will facilitate the scientific community to adopt alternative ways to improve the assessment of ADME, whether common or specific to each of these toxins.
· Develop a tiered testing strategy for volatile compounds. Different in vitro barrier models will be compared to model their absorption within the different regions of the respiratory tract
· Assess the impact of the human microbiome on the biotransformation of chemicals and their uptake into the systemic circulation
Acknowledgement: The European Partnership for the Assessment of Risks from Chemicals has received funding from the European Union’s Horizon Europe research and innovation program under Grant Agreement No.101057014 and has received co-funding of the authors’ institutions.
President:
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Application of TTC in food safety risk assessment in China
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TTC based on plasma concentrations (internal TTC)
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Development of TTC values for inhalable substances
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Thresholds for skin sensitization
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Application of the TTC concept to complex mixtures
Workshop 07: Strategic Assessment and Prioritization of Chemicals for Hazard and Risk Assessment[Workshop]
Governments and public health institutions especially in developing countries often need guidance and support in identifying and prioritizing chemicals and settings for risk assessment. Navigating the existing resources can be challenging, particularly when capacity is limited. The WHO Chemical Risk Assessment Network is developing and piloting a decision-making framework to help strengthen country capacity and infrastructure to identify, prioritize, and evaluate their chemical inventories for potential toxicity and risks to human health. The framework promotes existing tools and international mechanisms for chemicals management, in user-friendly and readily accessible formats, which promotes harmonization and reduces duplication of efforts. The framework was informed by a survey of the needs, tools and capacity of some developing country institutions within the Network. This session provides an overview of the framework, highlights the value in prioritizing chemicals and settings for risk assessment, and includes illustrative case studies and lessons learned from developed and developing countries. The case studies have assessed known and listed problematic compounds in the European Union, industrial chemicals, active pharmaceutic ingredients, pesticides, inorganic compounds, metals, organic compounds, highly toxic chemicals, and more, demonstrating wide applicability and utility. Prioritization frameworks based on health risks enable more cost-effective risk management and protection of public health.
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A semi-quantitative risk-based prioritization scheme for chemicals of concern in Nordic countries
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Multi-country regulatory data-driven hazard assessment for the prioritization of chemicals
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Risk-based prioritization of chemicals
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A tiered decision-making framework for identifying and prioritizing national chemical inventories for risk assessment
Workshop 08: Joining Forces towards the Human Exposome Project[Workshop]
Four decades after the Human Genome Project began, it is clear that genetics explains only a fraction of overall disease risk. The primary driver of health and disease is exposure—encompassing physicochemical, lifestyle, and environmental factors. However, a significant gap remains in the quantitative understanding of these influences. The Human Exposome Project aims to systematically explore and catalog these exposures, paralleling the genomic revolution in human biology. This initiative seeks to train a new generation of scientists dedicated to unraveling the complex environmental determinants of health. By fostering global collaboration, the project will unite researchers collecting exposome data, working toward a standardized framework to define the exposome and address critical knowledge and methodological gaps. This workshop will highlight the challenges in exposome research and outline the technological and conceptual advancements needed to drive the field forward. Through international cooperation, the Human Exposome Project has the potential to transform our understanding of disease causation and prevention, ultimately complementing genomic insights with a more holistic view of human health.
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A call for a human exposome project
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Recent advances in China national human biomonitoring and exposomics research
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Rethinking health in the face of modern environmental risks: The role of exposomics
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ExposomeX: Integrative exposomic platform expedites discovery of “exposure-biology-disease” nexus
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Global harmonization for exposomics: Opportunities and challenges
