Session 01: The Serious Issue of Interference in Nanotoxicology[Symposium Program （Session）]
Nanotoxicology is defined as the study of the adverse effects of nanomaterials on living organisms and the ecosystems. In vivo and in vitro test systems are implemented to characterize nanomaterial induced toxicity and elucidate mode of action involved with the aim of prevention and amelioration of such adverse effects. To this end, validated test methods that are developed for conventional chemicals are required to further be validated if they are to be used for nanomaterials. In the literature, numerous publications investigating the toxicity of nanomaterials have implemented these test systems without giving due consideration to the possibility of nanomaterials interfering with these test systems. There are different ways that nanomaterials interfere with these assay systems which include absorption, adsorption, or by interacting with the substrate and/or product. They may also enhance or quench the intensity of fluorophores or have catalytic activity. Ignoring this aspect in nanotoxicology may lead to the production of erroneous results and in turn hinder the elucidating mechanisms of toxicity to help in the prevention and amelioration of the observed adverse effects.
For these reasons, time has come for scientific journals to reject work that still use assay systems that are known to produce interference by nanomaterials.
NO.:1
In vitro toxicity assays: Potential assay interferences by nanomaterials
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In vitro toxicity assays: Potential assay interferences by carbon-based nanomaterials
NO.:3
Necessity of accurate assessment of the rate limiting step in initiation of inflammation
NO.:4
Serious concern with big data: Criteria for journals to accept publications using assay systems with interference
Session 07: Organoids and Organ-on-a-chip in Toxicology[Symposium Program （Session）]
This session is dedicated to presenting reports on the technological advancements and applications of cutting-edge analytical platforms in the field of toxicology, with a particular emphasis on organoid and microphysiological system (MPS) platforms, as well as integrations with AI technology. Microphysiological systems, recognized as one of the World's Top 10 Emerging Technologies at the Davos Forum in 2016 and endorsed by the FDA 2.0 and FDA 3.0 frameworks, represent the forefront of in vitro toxicological research systems. This forum aims to assemble a distinguished panel of experts in MPS research, comprising Prof. Dan Tagle, the director of the US MPS Consortium, Prof. Uwe Marx, the chief scientist at TissUse, a pioneering German organ-on-a-chip enterprise, Prof. Thomas Hartung from Johns Hopkins University, Professor Jay Hickman affiliated with both Cornell University and Hesperos Inc., Prof. Seiichi Ishida from NIEH in Japan, and Dean and Prof. Gu Zhongze from Southeast University in China. These esteemed scholars will introduce novel technological paradigms for toxicological research and application, encompassing various microphysiological systems that mimic different human organs and spanning multiple model frameworks.
NO.:1
The innovation of organ-on-a-chip in toxicology research
NO.:2
Introduction of the development of MPS in Japan and their way to the regulatory acceptance
NO.:3
Human multi-organ-chips advancing from toxicology testing toward preclinical “safficacy” evaluation in vitro
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Qualifying the soluble and mechanical environments of microphysiological systems for enhanced regulatory utility
