Session 28: RNA Dysregulations and Environmental Carcinogenesis[Symposium Program （Session）]
The discovery and characterization of non-coding RNAs (ncRNAs) challenged the central dogma of molecular biology, representing a breakthrough in our understanding of RNA biology and functions. The 2024 Nobel Prize in Physiology or Medicine was awarded to two scientists who discovered small regulatory noncoding RNAs known as microRNAs, signifying the importance of noncoding RNA research. With the completion of the Encyclopedia of DNA Elements (ENCODE) Project and advances in genomic sequencing technologies, it is now known that human genome is pervasively transcribed, and a large portion of human genome is transcribed as ncRNAs. Many studies demonstrated that RNA dysregulations including ncRNAs play important roles in the development and progression of many human diseases, especially cancer although the mechanisms have not been well understood. Many chemical carcinogens are common environmental and occupational pollutants and important etiological factors for cancer and many other diseases. The effects of environmental carcinogens on RNA expressions and functions are exciting research fields in toxicology. The goals of this symposium are to introduce current research on RNA dysregulations in the field of toxicology, and to discuss the role and mechanism of RNA dysregulations in environmental carcinogenesis. To achieve these goals, this symposium convenes a panel of outstanding environmental carcinogenesis researchers. This symposium will attract an expanded ICTXVII audience of environmental carcinogenesis and other toxicology researchers.
President:
NO.:1
Circular RNA dysregulation and epigenomic reprogramming by iAs in carcinogenesis
NO.:2
Long noncoding RNA ABHD11-AS1 up-regulation promotes hexavalent chromium carcinogenesis
NO.:3
Regulatory mechanisms of circular RNAs in carbon black nanoparticle-induced DNA damage and malignant transformation of human airway epithelial cells
NO.:4
Role of RNA m6A methylation dysregulation in arsenic and benzo(a)pyrene co-exposure-induced cell transformation and tumorigenesis
NO.:5
Mechanisms of environmental carcinogenesis: how hexavalent chromium induces DNA repair dysregulation targeting RNA and protein
